Analysis of poly(ethylene glycol)-diacrylate macromer polymerization within a multicomponent semi-interpenetrating polymer network system

Semi‐interpenetrating polymer networks (semi‐IPNs) containing poly(ethylene glycol)‐diacrylate (PEGdA) and modified gelatin were prepared with 2,2‐dimethoxy‐2‐phenylacetophenone (DMPA) as a photoinitiator. The effect of (i) initiator and PEGdA concentration, and (ii) weight ratio and type of modifie...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2004-12, Vol.71A (3), p.508-518
Main Authors: Witte, Richard P., Blake, Alexander J., Palmer, Christine, Kao, Weiyuan John
Format: Article
Language:English
Subjects:
Acetophenones - chemistry
attenuated total reflectance-Fourier transform infrared (ATR-FTIR)
conversion
Gelatin - chemistry
hydrogels
Hydrogen - chemistry
Kinetics
Molecular Structure
photopolymerization
poly(ethylene glycol)-diacrylate
Polyethylene Glycols - chemistry
Polymers - chemistry
Spectroscopy, Fourier Transform Infrared
Ultraviolet Rays
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Summary:Semi‐interpenetrating polymer networks (semi‐IPNs) containing poly(ethylene glycol)‐diacrylate (PEGdA) and modified gelatin were prepared with 2,2‐dimethoxy‐2‐phenylacetophenone (DMPA) as a photoinitiator. The effect of (i) initiator and PEGdA concentration, and (ii) weight ratio and type of modified gelatin on the conversion of PEGdA functional end groups was monitored in situ using attenuated total reflectance‐Fourier transform infrared (ATR‐FTIR). Reaction induction time was dependent on DMPA concentration and increased with decreasing DMPA concentration. Relative reaction rate was strongly dependent on both DMPA and PEGdA concentrations. Gelatin weight ratio and modification did not significantly affect reaction induction time, relative reaction rate, or reaction end time. Swelling/degradation kinetics at various aqueous conditions sought to establish relationships between diacrylate conversion and the resulting semi‐IPN physical properties. Semi‐IPN swelling weight ratio was strongly dependent on solvent conditions and semi‐IPN exposure to γ‐irradiation. Gelatin backbone modification and UV exposure time exhibited no effect on semi‐IPN swelling weight ratio. In conclusion, ATR‐FTIR presents a viable means of monitoring the conversion of PEGdA functional end groups within a complex mixture. UV exposure >10 s did not significantly affect the weight swelling ratio, and supports our ATR‐FTIR results that network formation reached completion before 3 min of UV exposure. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 71A: 508–518, 2004
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.30179