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Alcohol intake is not associated with subclinical coronary atherosclerosis
The inverse relation between alcohol intake and clinical coronary artery disease (CAD) is well established, although the mechanisms remain speculative. We studied the relation between alcohol intake and subclinical CAD to assess the possible role of alcohol in atherogenesis. We conducted a prospecti...
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Published in: | The American heart journal 2004-11, Vol.148 (5), p.803-809 |
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description | The inverse relation between alcohol intake and clinical coronary artery disease (CAD) is well established, although the mechanisms remain speculative. We studied the relation between alcohol intake and subclinical CAD to assess the possible role of alcohol in atherogenesis.
We conducted a prospective study of 731 consecutive, consenting, active-duty US Army personnel (39 to 45 years of age) without known CAD who were undergoing a routine physical examination. Each participant was surveyed with the validated Block dietary questionnaire, which included detailed information on alcohol intake as wine, beer, or liquor. Subclinical CAD was determined by means of electron beam computed tomography to quantify coronary artery calcification (CAC).
The mean age was 42 (±2); 83% were male, 71% were white, and 82% were college graduates. The prevalence of CAC was 18.6% (mean CAC score = 12 ± 69). Twenty-two percent drank alcohol daily, with an average of 2.4 drinks per day. Systolic blood pressure was correlated with number of drinks per day (
r = 0.10,
P = .025). Among drinkers, HDL was weakly correlated with daily alcohol consumption (
r = 0.10,
P = .025). There was no relation between the CAC score and the alcohol intake as measured by drinks per day (OR, 1.02; 95% CI, 0.64 to 1.63; 1.13, 0.59 to 2.15; 1.26, 0.69 to 2.59, for less than 1, 1 to 2, and more than 2 drinks per day, respectively). Stratified analyses based on type of alcohol and multivariate analyses indicated no independent relation between any type or quantity of alcohol intake and the presence or extent of coronary calcification.
Alcohol intake does not appear to be inversely related to subclinical CAC, implying that previous observations of a protective effect of alcohol on clinical CAD may involve factors related to plaque stability rather than atherogenesis. |
doi_str_mv | 10.1016/j.ahj.2004.05.023 |
format | article |
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We conducted a prospective study of 731 consecutive, consenting, active-duty US Army personnel (39 to 45 years of age) without known CAD who were undergoing a routine physical examination. Each participant was surveyed with the validated Block dietary questionnaire, which included detailed information on alcohol intake as wine, beer, or liquor. Subclinical CAD was determined by means of electron beam computed tomography to quantify coronary artery calcification (CAC).
The mean age was 42 (±2); 83% were male, 71% were white, and 82% were college graduates. The prevalence of CAC was 18.6% (mean CAC score = 12 ± 69). Twenty-two percent drank alcohol daily, with an average of 2.4 drinks per day. Systolic blood pressure was correlated with number of drinks per day (
r = 0.10,
P = .025). Among drinkers, HDL was weakly correlated with daily alcohol consumption (
r = 0.10,
P = .025). There was no relation between the CAC score and the alcohol intake as measured by drinks per day (OR, 1.02; 95% CI, 0.64 to 1.63; 1.13, 0.59 to 2.15; 1.26, 0.69 to 2.59, for less than 1, 1 to 2, and more than 2 drinks per day, respectively). Stratified analyses based on type of alcohol and multivariate analyses indicated no independent relation between any type or quantity of alcohol intake and the presence or extent of coronary calcification.
Alcohol intake does not appear to be inversely related to subclinical CAC, implying that previous observations of a protective effect of alcohol on clinical CAD may involve factors related to plaque stability rather than atherogenesis.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/j.ahj.2004.05.023</identifier><identifier>PMID: 15523310</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Alcohol Drinking ; Alcohol use ; Analysis of Variance ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Beer ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood pressure ; Calcinosis - diagnostic imaging ; Calcinosis - prevention & control ; Cardiology. Vascular system ; Cardiovascular disease ; Cholesterol ; Confidence intervals ; Coronary Artery Disease - etiology ; Coronary Disease - diagnostic imaging ; Coronary Disease - prevention & control ; Coronary heart disease ; Coronary vessels ; Family medical history ; Female ; Heart ; Heart attacks ; Humans ; Hypertension ; Liquor ; Logistic Models ; Low density lipoprotein ; Male ; Medical sciences ; Middle Aged ; Risk Factors ; Tomography, X-Ray Computed</subject><ispartof>The American heart journal, 2004-11, Vol.148 (5), p.803-809</ispartof><rights>2004 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Elsevier Limited Nov 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-72908177258c7dcdbaba45c7ed25073516575c60ed8ff4421f442850060ef1893</citedby><cites>FETCH-LOGICAL-c409t-72908177258c7dcdbaba45c7ed25073516575c60ed8ff4421f442850060ef1893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16268706$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15523310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tofferi, Jeanne K.</creatorcontrib><creatorcontrib>Taylor, Allen J.</creatorcontrib><creatorcontrib>Feuerstein, Irwin M.</creatorcontrib><creatorcontrib>O'Malley, Patrick G.</creatorcontrib><title>Alcohol intake is not associated with subclinical coronary atherosclerosis</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>The inverse relation between alcohol intake and clinical coronary artery disease (CAD) is well established, although the mechanisms remain speculative. We studied the relation between alcohol intake and subclinical CAD to assess the possible role of alcohol in atherogenesis.
We conducted a prospective study of 731 consecutive, consenting, active-duty US Army personnel (39 to 45 years of age) without known CAD who were undergoing a routine physical examination. Each participant was surveyed with the validated Block dietary questionnaire, which included detailed information on alcohol intake as wine, beer, or liquor. Subclinical CAD was determined by means of electron beam computed tomography to quantify coronary artery calcification (CAC).
The mean age was 42 (±2); 83% were male, 71% were white, and 82% were college graduates. The prevalence of CAC was 18.6% (mean CAC score = 12 ± 69). Twenty-two percent drank alcohol daily, with an average of 2.4 drinks per day. Systolic blood pressure was correlated with number of drinks per day (
r = 0.10,
P = .025). Among drinkers, HDL was weakly correlated with daily alcohol consumption (
r = 0.10,
P = .025). There was no relation between the CAC score and the alcohol intake as measured by drinks per day (OR, 1.02; 95% CI, 0.64 to 1.63; 1.13, 0.59 to 2.15; 1.26, 0.69 to 2.59, for less than 1, 1 to 2, and more than 2 drinks per day, respectively). Stratified analyses based on type of alcohol and multivariate analyses indicated no independent relation between any type or quantity of alcohol intake and the presence or extent of coronary calcification.
Alcohol intake does not appear to be inversely related to subclinical CAC, implying that previous observations of a protective effect of alcohol on clinical CAD may involve factors related to plaque stability rather than atherogenesis.</description><subject>Adult</subject><subject>Alcohol Drinking</subject><subject>Alcohol use</subject><subject>Analysis of Variance</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Beer</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood pressure</subject><subject>Calcinosis - diagnostic imaging</subject><subject>Calcinosis - prevention & control</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Confidence intervals</subject><subject>Coronary Artery Disease - etiology</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - prevention & control</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Family medical history</subject><subject>Female</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Liquor</subject><subject>Logistic Models</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Tomography, X-Ray Computed</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp9kU1r3DAQhkVoSDYfP6CXYijNzc5I1odNTyEkbUMgl_YstOMxK9drpZKd0H8fLbsQ6KGXEYJnhnmfYewjh4oD19dD5TZDJQBkBaoCUR-xFYfWlNpI-YGtAECUjYH6lJ2lNOSvFo0-YadcKVHXHFbs4WbEsAlj4afZ_abCp2IKc-FSCujdTF3x6udNkZY1jn7y6MYCQwyTi38LN28ohoTjrvp0wY57Nya6PLzn7Nf93c_b7-Xj07cftzePJUpo59KIFhpujFANmg67tVs7qdBQJxSYWnGtjEIN1DV9L6Xgu9KovDtQz5u2PmdX-7nPMfxZKM126xPSOLqJwpKszoHbWkMGP_8DDmGJU97NcgVSGgDFM8X3FOYUKVJvn6Pf5nyWg91ptoPNmu1OswVls-bc8-kweVlvqXvvOHjNwJcD4FJ21kc3oU_vnBY630Vn7uueoyzsxVO0CT1NSJ2PhLPtgv_PGm_xzZjA</recordid><startdate>20041101</startdate><enddate>20041101</enddate><creator>Tofferi, Jeanne K.</creator><creator>Taylor, Allen J.</creator><creator>Feuerstein, Irwin M.</creator><creator>O'Malley, Patrick G.</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20041101</creationdate><title>Alcohol intake is not associated with subclinical coronary atherosclerosis</title><author>Tofferi, Jeanne K. ; Taylor, Allen J. ; Feuerstein, Irwin M. ; O'Malley, Patrick G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-72908177258c7dcdbaba45c7ed25073516575c60ed8ff4421f442850060ef1893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Alcohol Drinking</topic><topic>Alcohol use</topic><topic>Analysis of Variance</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Beer</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood pressure</topic><topic>Calcinosis - diagnostic imaging</topic><topic>Calcinosis - prevention & control</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Confidence intervals</topic><topic>Coronary Artery Disease - etiology</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Disease - prevention & control</topic><topic>Coronary heart disease</topic><topic>Coronary vessels</topic><topic>Family medical history</topic><topic>Female</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Liquor</topic><topic>Logistic Models</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tofferi, Jeanne K.</creatorcontrib><creatorcontrib>Taylor, Allen J.</creatorcontrib><creatorcontrib>Feuerstein, Irwin M.</creatorcontrib><creatorcontrib>O'Malley, Patrick G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Health Management Database</collection><collection>Medical Database</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tofferi, Jeanne K.</au><au>Taylor, Allen J.</au><au>Feuerstein, Irwin M.</au><au>O'Malley, Patrick G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alcohol intake is not associated with subclinical coronary atherosclerosis</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2004-11-01</date><risdate>2004</risdate><volume>148</volume><issue>5</issue><spage>803</spage><epage>809</epage><pages>803-809</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>The inverse relation between alcohol intake and clinical coronary artery disease (CAD) is well established, although the mechanisms remain speculative. We studied the relation between alcohol intake and subclinical CAD to assess the possible role of alcohol in atherogenesis.
We conducted a prospective study of 731 consecutive, consenting, active-duty US Army personnel (39 to 45 years of age) without known CAD who were undergoing a routine physical examination. Each participant was surveyed with the validated Block dietary questionnaire, which included detailed information on alcohol intake as wine, beer, or liquor. Subclinical CAD was determined by means of electron beam computed tomography to quantify coronary artery calcification (CAC).
The mean age was 42 (±2); 83% were male, 71% were white, and 82% were college graduates. The prevalence of CAC was 18.6% (mean CAC score = 12 ± 69). Twenty-two percent drank alcohol daily, with an average of 2.4 drinks per day. Systolic blood pressure was correlated with number of drinks per day (
r = 0.10,
P = .025). Among drinkers, HDL was weakly correlated with daily alcohol consumption (
r = 0.10,
P = .025). There was no relation between the CAC score and the alcohol intake as measured by drinks per day (OR, 1.02; 95% CI, 0.64 to 1.63; 1.13, 0.59 to 2.15; 1.26, 0.69 to 2.59, for less than 1, 1 to 2, and more than 2 drinks per day, respectively). Stratified analyses based on type of alcohol and multivariate analyses indicated no independent relation between any type or quantity of alcohol intake and the presence or extent of coronary calcification.
Alcohol intake does not appear to be inversely related to subclinical CAC, implying that previous observations of a protective effect of alcohol on clinical CAD may involve factors related to plaque stability rather than atherogenesis.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>15523310</pmid><doi>10.1016/j.ahj.2004.05.023</doi><tpages>7</tpages></addata></record> |
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subjects | Adult Alcohol Drinking Alcohol use Analysis of Variance Atherosclerosis Atherosclerosis (general aspects, experimental research) Beer Biological and medical sciences Blood and lymphatic vessels Blood pressure Calcinosis - diagnostic imaging Calcinosis - prevention & control Cardiology. Vascular system Cardiovascular disease Cholesterol Confidence intervals Coronary Artery Disease - etiology Coronary Disease - diagnostic imaging Coronary Disease - prevention & control Coronary heart disease Coronary vessels Family medical history Female Heart Heart attacks Humans Hypertension Liquor Logistic Models Low density lipoprotein Male Medical sciences Middle Aged Risk Factors Tomography, X-Ray Computed |
title | Alcohol intake is not associated with subclinical coronary atherosclerosis |
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