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Alcohol intake is not associated with subclinical coronary atherosclerosis

The inverse relation between alcohol intake and clinical coronary artery disease (CAD) is well established, although the mechanisms remain speculative. We studied the relation between alcohol intake and subclinical CAD to assess the possible role of alcohol in atherogenesis. We conducted a prospecti...

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Published in:The American heart journal 2004-11, Vol.148 (5), p.803-809
Main Authors: Tofferi, Jeanne K., Taylor, Allen J., Feuerstein, Irwin M., O'Malley, Patrick G.
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description The inverse relation between alcohol intake and clinical coronary artery disease (CAD) is well established, although the mechanisms remain speculative. We studied the relation between alcohol intake and subclinical CAD to assess the possible role of alcohol in atherogenesis. We conducted a prospective study of 731 consecutive, consenting, active-duty US Army personnel (39 to 45 years of age) without known CAD who were undergoing a routine physical examination. Each participant was surveyed with the validated Block dietary questionnaire, which included detailed information on alcohol intake as wine, beer, or liquor. Subclinical CAD was determined by means of electron beam computed tomography to quantify coronary artery calcification (CAC). The mean age was 42 (±2); 83% were male, 71% were white, and 82% were college graduates. The prevalence of CAC was 18.6% (mean CAC score = 12 ± 69). Twenty-two percent drank alcohol daily, with an average of 2.4 drinks per day. Systolic blood pressure was correlated with number of drinks per day ( r = 0.10, P = .025). Among drinkers, HDL was weakly correlated with daily alcohol consumption ( r = 0.10, P = .025). There was no relation between the CAC score and the alcohol intake as measured by drinks per day (OR, 1.02; 95% CI, 0.64 to 1.63; 1.13, 0.59 to 2.15; 1.26, 0.69 to 2.59, for less than 1, 1 to 2, and more than 2 drinks per day, respectively). Stratified analyses based on type of alcohol and multivariate analyses indicated no independent relation between any type or quantity of alcohol intake and the presence or extent of coronary calcification. Alcohol intake does not appear to be inversely related to subclinical CAC, implying that previous observations of a protective effect of alcohol on clinical CAD may involve factors related to plaque stability rather than atherogenesis.
doi_str_mv 10.1016/j.ahj.2004.05.023
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Among drinkers, HDL was weakly correlated with daily alcohol consumption ( r = 0.10, P = .025). There was no relation between the CAC score and the alcohol intake as measured by drinks per day (OR, 1.02; 95% CI, 0.64 to 1.63; 1.13, 0.59 to 2.15; 1.26, 0.69 to 2.59, for less than 1, 1 to 2, and more than 2 drinks per day, respectively). Stratified analyses based on type of alcohol and multivariate analyses indicated no independent relation between any type or quantity of alcohol intake and the presence or extent of coronary calcification. Alcohol intake does not appear to be inversely related to subclinical CAC, implying that previous observations of a protective effect of alcohol on clinical CAD may involve factors related to plaque stability rather than atherogenesis.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>15523310</pmid><doi>10.1016/j.ahj.2004.05.023</doi><tpages>7</tpages></addata></record>
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ispartof The American heart journal, 2004-11, Vol.148 (5), p.803-809
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source ScienceDirect Journals
subjects Adult
Alcohol Drinking
Alcohol use
Analysis of Variance
Atherosclerosis
Atherosclerosis (general aspects, experimental research)
Beer
Biological and medical sciences
Blood and lymphatic vessels
Blood pressure
Calcinosis - diagnostic imaging
Calcinosis - prevention & control
Cardiology. Vascular system
Cardiovascular disease
Cholesterol
Confidence intervals
Coronary Artery Disease - etiology
Coronary Disease - diagnostic imaging
Coronary Disease - prevention & control
Coronary heart disease
Coronary vessels
Family medical history
Female
Heart
Heart attacks
Humans
Hypertension
Liquor
Logistic Models
Low density lipoprotein
Male
Medical sciences
Middle Aged
Risk Factors
Tomography, X-Ray Computed
title Alcohol intake is not associated with subclinical coronary atherosclerosis
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