Chemoenzymatic syntheses of carbasugar analogues of nucleoside diphosphate sugars: UDP-carba-Gal, UDP-carba-GlcNAc, UDP-carba-Glc, and GDP-carba-Man

Chemoenzymatic syntheses of several NDP-carba-sugars have been successfully carried out, and these essential cofactor analogues are expected to be selective inhibitors of glycosyltransferase enzymes.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2009-01 (13), p.1733-1735
Main Authors: Seo, Kyung-Chang, Kwon, Young-Geol, Kim, Dae-Hee, Jang, In-Sook, Cho, Jin-Won, Chung, Sung-Kee
Format: Article
Language:English
Subjects:
Enzymes - chemistry
Nucleoside Diphosphate Sugars - chemical synthesis
Nucleoside Diphosphate Sugars - chemistry
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Description
Summary:Chemoenzymatic syntheses of several NDP-carba-sugars have been successfully carried out, and these essential cofactor analogues are expected to be selective inhibitors of glycosyltransferase enzymes.
ISSN:1359-7345
1364-548X
DOI:10.1039/b821058f