Compartmentalized signalling: Ca²⁺ compartments, microdomains and the many facets of Ca²⁺ signalling

Ca²⁺ regulates a multitude of cellular processes and does so by partitioning its actions in space and time. In this review, we discuss how Ca²⁺ responses are constructed from small quantal (elementary) events that have the potential to propagate to produce large pan-cellular responses. We review how...

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Bibliographic Details
Published in:The FEBS journal 2009-04, Vol.276 (7), p.1800-1816
Main Authors: Laude, Alex J, Simpson, Alec W.M
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Calcium
Calcium - metabolism
Calcium Signaling - physiology
calcium store
Cell Compartmentation - physiology
Cell Nucleus - metabolism
Cellular biology
CICR
compartmentalized
cyclic ADP-ribose
Cytoplasm - metabolism
Humans
inositol trisphosphate receptor
Membrane Microdomains - metabolism
microdomains
Mitochondria - metabolism
Models, Biological
NADP (coenzyme)
nicotinamide adenine dinucleotide phosphate
organelle
ryanodine intracellular receptor
Signal Transduction
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Summary:Ca²⁺ regulates a multitude of cellular processes and does so by partitioning its actions in space and time. In this review, we discuss how Ca²⁺ responses are constructed from small quantal (elementary) events that have the potential to propagate to produce large pan-cellular responses. We review how Ca²⁺ is compartmentalized both physically and functionally, and describe how each organelle has its own distinct Ca²⁺-handling properties. We explain how coordination of the movement of Ca²⁺ between organelles is used to shape and hone Ca²⁺ signals. Finally, we provide a number of specific examples of where compartmentation and localization of Ca²⁺ are crucial to cell function.
ISSN:1742-464X
1742-4658
DOI:10.1111/j.1742-4658.2009.06927.x