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Compartmentalized signalling: Ca²⁺ compartments, microdomains and the many facets of Ca²⁺ signalling
Ca²⁺ regulates a multitude of cellular processes and does so by partitioning its actions in space and time. In this review, we discuss how Ca²⁺ responses are constructed from small quantal (elementary) events that have the potential to propagate to produce large pan-cellular responses. We review how...
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| Published in: | The FEBS journal 2009-04, Vol.276 (7), p.1800-1816 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| container_end_page | 1816 |
| container_issue | 7 |
| container_start_page | 1800 |
| container_title | The FEBS journal |
| container_volume | 276 |
| creator | Laude, Alex J Simpson, Alec W.M |
| description | Ca²⁺ regulates a multitude of cellular processes and does so by partitioning its actions in space and time. In this review, we discuss how Ca²⁺ responses are constructed from small quantal (elementary) events that have the potential to propagate to produce large pan-cellular responses. We review how Ca²⁺ is compartmentalized both physically and functionally, and describe how each organelle has its own distinct Ca²⁺-handling properties. We explain how coordination of the movement of Ca²⁺ between organelles is used to shape and hone Ca²⁺ signals. Finally, we provide a number of specific examples of where compartmentation and localization of Ca²⁺ are crucial to cell function. |
| doi_str_mv | 10.1111/j.1742-4658.2009.06927.x |
| format | article |
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| identifier | ISSN: 1742-464X |
| ispartof | The FEBS journal, 2009-04, Vol.276 (7), p.1800-1816 |
| issn | 1742-464X 1742-4658 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Biochemistry Calcium Calcium - metabolism Calcium Signaling - physiology calcium store Cell Compartmentation - physiology Cell Nucleus - metabolism Cellular biology CICR compartmentalized cyclic ADP-ribose Cytoplasm - metabolism Humans inositol trisphosphate receptor Membrane Microdomains - metabolism microdomains Mitochondria - metabolism Models, Biological NADP (coenzyme) nicotinamide adenine dinucleotide phosphate organelle ryanodine intracellular receptor Signal Transduction |
| title | Compartmentalized signalling: Ca²⁺ compartments, microdomains and the many facets of Ca²⁺ signalling |
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