Some lessons from the tissue transglutaminase knockout mouse

Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca²⁺-dependent protein modifications. It acts as a G protein in transmembrane signaling and as a cell surface adhesion mediator, this distinguishes it from other members of the transglutaminase family. The sequenc...

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Bibliographic Details
Published in:Amino acids 2009-04, Vol.36 (4), p.625-631
Main Authors: Sarang, Z, Tóth, B, Balajthy, Z, Köröskényi, K, Garabuczi, É, Fésüs, L, Szondy, Z
Format: Article
Language:English
Subjects:
Adhesion
Amino acids
Analytical Chemistry
Animals
Biochemical Engineering
Biochemistry
Biological
Biomedical and Life Sciences
Biomedical materials
Cell adhesion & migration
Conserved Sequence
Control
GTP-Binding Proteins - chemistry
GTP-Binding Proteins - deficiency
GTP-Binding Proteins - metabolism
In vivo testing
In vivo tests
Life Sciences
Mice
Mice, Knockout
Neurobiology
Protein Structure, Tertiary
Proteins
Proteomics
Review Article
Transglutaminases - chemistry
Transglutaminases - deficiency
Transglutaminases - metabolism
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Summary:Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca²⁺-dependent protein modifications. It acts as a G protein in transmembrane signaling and as a cell surface adhesion mediator, this distinguishes it from other members of the transglutaminase family. The sequence motifs and domains revealed in the TG2 structure, can each be assigned distinct cellular functions, including the regulation of cytoskeleton, cell adhesion, and cell death. Though many biological functions of the enzyme have already been described or proposed previously, studies of TG2 null mice by our laboratory during the past years revealed several novel in vivo roles of the protein. In this review we will discuss these novel roles in their biological context.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-008-0130-x