Kinase Domain Mutations in Cancer: Implications for Small Molecule Drug Design Strategies

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Bibliographic Details
Published in:Journal of medicinal chemistry 2009-03, Vol.52 (6), p.1493-1509
Main Authors: Bikker, Jack A, Brooijmans, Natasja, Wissner, Allan, Mansour, Tarek S
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Antineoplastic agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Drug Design
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Enzyme Inhibitors - therapeutic use
General aspects
Humans
Medical sciences
Molecular Sequence Data
Mutation
Neoplasms - drug therapy
Neoplasms - enzymology
Pharmacology. Drug treatments
Phosphotransferases - antagonists & inhibitors
Phosphotransferases - chemistry
Phosphotransferases - genetics
Protein Conformation
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ISSN:0022-2623
1520-4804
DOI:10.1021/jm8010542