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Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain
In the present work, the expression patterns of the Wnt antagonists of the Dickkopf (Dkk) family were characterized in the developing mouse forebrain. In situ hybridisation on sections from E12 embryos showed an expression of dkk2 in the thalamus and dkk3 in the cortical hem and thalamus. At later d...
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Published in: | Brain research. Developmental brain research 2004-11, Vol.153 (2), p.261-270 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | In the present work, the expression patterns of the Wnt antagonists of the Dickkopf (Dkk) family were characterized in the developing mouse forebrain. In situ hybridisation on sections from E12 embryos showed an expression of
dkk2 in the thalamus and
dkk3 in the cortical hem and thalamus. At later developmental stages (E15.5, E17.5, and P0), little or no expression of
dkk1,
dkk2, and
dkk4 was found in the forebrain, while
dkk3 expression was detected in the ventricular zone (VZ) of the lateral and III ventricles, cortical neurons, migrating cells of the primary and secondary dentate migration, and the neuroblastic layer of the eye. In the adult forebrain,
dkk3 expression was detected in the lateral VZ, pyramidal neurons of the hippocampus, and cortical neurons. We also provide evidence indicating that only
dkk1 and
dkk4, along with two other Wnt antagonists
axin2 and
wif1, but not
dkk2 and
dkk3, are involved in a feedback mechanism to restrain Wnt signalling in transgenic mice carrying a conditional augmentation of β-catenin in the forebrain. |
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ISSN: | 0165-3806 |
DOI: | 10.1016/j.devbrainres.2004.09.008 |