Cancer preceding Wegener's granulomatosis: a case–control study

Objective. To investigate whether patients with WG have an increased risk of malignancies prior to and/or around the time of the vasculitis diagnosis, as suggested by previous studies. Methods. A total of 293 WG patients were included in the study. Ten gender- and age-matched controls were selected...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2009-04, Vol.48 (4), p.421-424
Main Authors: Faurschou, Mikkel, Mellemkjaer, Lene, Sorensen, Inge J., Thomsen, Bjarne S., Dreyer, Lene, Baslund, Bo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cancer
Case-Control Studies
Case–control study
Denmark
Dermatology
Diseases of the osteoarticular system
Female
Granulomatosis with Polyangiitis - complications
Granulomatosis with Polyangiitis - diagnosis
Humans
Male
Malignancy
Medical sciences
Middle Aged
Neoplasms - complications
Neoplasms - diagnosis
Non-melanoma skin cancer
Odds Ratio
Prevalence
Risk
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Skin Neoplasms - complications
Testicular Neoplasms - complications
Tumors of the skin and soft tissue. Premalignant lesions
Vasculitis
Vasculitis - complications
Vasculitis - diagnosis
Wegener's granulomatosis
Young Adult
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Summary:Objective. To investigate whether patients with WG have an increased risk of malignancies prior to and/or around the time of the vasculitis diagnosis, as suggested by previous studies. Methods. A total of 293 WG patients were included in the study. Ten gender- and age-matched controls were selected randomly for each patient from the Danish Central Population Register. Information on malignancies was obtained through the Danish Cancer Registry. Occurrence of malignancies before WG diagnosis among patients and before WG diagnosis of their matched case among controls (reference date) was compared by calculation of prevalence odds ratios (OR). Results. Twenty-six patients were diagnosed with cancer before WG, while 194 controls were diagnosed with cancer before the reference date (OR 1.4; 95% CI 0.9, 2.2). Among specific malignancies, a significantly increased prevalence was found for testis cancer (OR 6.4; 95% CI 1.1, 38) based on two patients, who developed testis cancer >10 years before WG. The overall prevalence of malignancies diagnosed
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/kep009