Effectiveness of pamidronate in severe neonatal hypercalcemia caused by subcutaneous fat necrosis: a case report

Subcutaneous fat necrosis of the newborn (SCFN) is a panniculitis that develops in fatty areas during the first weeks of life after foetal distress or perinatal complications. Prognosis is generally good with complete regression, but it can be complicated by metabolic abnormalities like hypoglycemia...

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Bibliographic Details
Published in:European journal of pediatrics 2009-05, Vol.168 (5), p.625-627
Main Authors: Lombardi, G., Cabano, R., Bollani, L., Del Forno, C., Stronati, M.
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - therapeutic use
Biological and medical sciences
Child
Child, Preschool
Diphosphonates - therapeutic use
Fat Necrosis - complications
Fat Necrosis - pathology
Female
General aspects
Humans
Hypercalcemia - drug therapy
Hypercalcemia - etiology
Medical sciences
Medicine
Medicine & Public Health
Pediatrics
Short Report
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Summary:Subcutaneous fat necrosis of the newborn (SCFN) is a panniculitis that develops in fatty areas during the first weeks of life after foetal distress or perinatal complications. Prognosis is generally good with complete regression, but it can be complicated by metabolic abnormalities like hypoglycemia, hypertriglyceridemia, thrombocytopenia, and also potentially life-threatening hypercalcemia. We report a case of severe hypercalcemia complicating SCFN in a newborn who was treated with hyperhydration, furosemide, prednisone, and pamidronate.
ISSN:0340-6199
1432-1076
DOI:10.1007/s00431-008-0797-8