Isoforms of Vitamin E Have Opposing Immunoregulatory Functions during Inflammation by Regulating Leukocyte Recruitment

Reports indicate contradictory outcomes for anti-inflammatory functions of the alpha-tocopherol isoform of vitamin E in clinical studies of asthma and atherosclerosis. These seemingly disparate clinical results are consistent with novel unrecognized properties of isoforms of vitamin E reported in th...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2009-04, Vol.182 (7), p.4395-4405
Main Authors: Berdnikovs, Sergejs, Abdala-Valencia, Hiam, McCary, Christine, Somand, Michelle, Cole, Rokeisha, Garcia, Alex, Bryce, Paul, Cook-Mills, Joan M
Format: Article
Language:English
Subjects:
Animals
Asthma - immunology
Blotting, Western
Bronchoalveolar Lavage Fluid - chemistry
Chemotaxis, Leukocyte - drug effects
Chemotaxis, Leukocyte - immunology
Cytokines - analysis
Cytokines - drug effects
Disease Models, Animal
Endothelial Cells - drug effects
Endothelial Cells - metabolism
Female
Humans
Inflammation - immunology
Lung - drug effects
Lung - immunology
Lung - pathology
Mice
Mice, Inbred BALB C
Plant Oils - chemistry
Protein Isoforms
Vitamin E - blood
Vitamin E - pharmacology
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Summary:Reports indicate contradictory outcomes for anti-inflammatory functions of the alpha-tocopherol isoform of vitamin E in clinical studies of asthma and atherosclerosis. These seemingly disparate clinical results are consistent with novel unrecognized properties of isoforms of vitamin E reported in this study. We demonstrate that the isoform d-gamma-tocopherol elevates inflammation in experimental asthma. Moreover, d-gamma-tocopherol, at as little as 10% the concentration of d-alpha-tocopherol, ablates the anti-inflammatory benefit of the d-alpha-tocopherol isoform. A mechanism for these opposing immunoregulatory functions of purified tocopherols at physiological concentrations is not through modulation of expression of several cytokines, chemokines, or adhesion molecules, but is, at least in part, by regulation of endothelial cell signals during leukocyte recruitment. These opposing regulatory functions of vitamin E isoforms have impact on interpretations of vitamin E studies. In summary, our studies with purified tocopherol isoforms alter our understanding of vitamin E regulation of vascular function and asthma.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.0803659