Report on the Use of Poly(organophosphazenes) for the Design of Stimuli-Responsive Vesicles

A novel family of amphiphilic temperature- and pH-sensitive poly(organophosphazenes) with varying ratios of ethylene oxide, alkyl chains and free acid units was synthesized by living cationic polymerization. Depending on their composition, these poly(organophosphazenes) exhibited lower critical solu...

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Bibliographic Details
Published in:Biomacromolecules 2004-11, Vol.5 (6), p.2082-2087
Main Authors: Couffin-Hoarau, Anne-Claude, Leroux, Jean-Christophe
Format: Article
Language:English
Subjects:
Applied sciences
Biocompatible Materials - chemistry
Biological and medical sciences
Biotechnology - methods
Cations
Drug Carriers - chemistry
Drug Delivery Systems
Ethylene Oxide - chemistry
Exact sciences and technology
General pharmacology
Hydrogen-Ion Concentration
Inorganic and organomineral polymers
Kinetics
Liposomes - chemistry
Medical sciences
Models, Chemical
Organophosphorus Compounds - chemistry
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Polymers - chemistry
Preparation
Temperature
Time Factors
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Summary:A novel family of amphiphilic temperature- and pH-sensitive poly(organophosphazenes) with varying ratios of ethylene oxide, alkyl chains and free acid units was synthesized by living cationic polymerization. Depending on their composition, these poly(organophosphazenes) exhibited lower critical solution temperatures ranging from 32 to 44°C, which were pH-dependent for copolymers bearing carboxylic acid groups. The alkylated copolymers were then anchored into phospholipid bilayers to obtain stimuli-responsive liposomes that released their content upon a change in temperature or pH. Such polymer/vesicle complexes could find practical applications for site-specific and intracellular drug delivery.
ISSN:1525-7797
1526-4602
DOI:10.1021/bm0400527