In Situ Gelling of Alginate/Pluronic Solutions for Ophthalmic Delivery of Pilocarpine

We prepared a series of alginate and Pluronic-based solutions as the in situ gelling vehicles for ophthalmic delivery of pilocarpine. The rheological properties, in vitro release as well as in vivo pharmacological response of polymer solutions, including alginate, Pluronic solution, and alginate/Plu...

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Bibliographic Details
Published in:Biomacromolecules 2004-11, Vol.5 (6), p.2358-2365
Main Authors: Lin, Hong-Ru, Sung, K. C, Vong, Wen-Jong
Format: Article
Language:English
Subjects:
Alginates - administration & dosage
Animals
Applied sciences
Area Under Curve
Biocompatible Materials
Biological and medical sciences
Biophysical Phenomena
Biophysics
Drug Delivery Systems
Exact sciences and technology
Eye - drug effects
Female
General pharmacology
Hydrogen-Ion Concentration
Male
Medical sciences
Natural polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Pilocarpine - administration & dosage
Polymers - administration & dosage
Polymers - chemistry
Polysaccharides - chemistry
Rabbits
Rheology
Starch and polysaccharides
Temperature
Time Factors
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Summary:We prepared a series of alginate and Pluronic-based solutions as the in situ gelling vehicles for ophthalmic delivery of pilocarpine. The rheological properties, in vitro release as well as in vivo pharmacological response of polymer solutions, including alginate, Pluronic solution, and alginate/Pluronic solution, were evaluated. The optimum concentration of alginate solution for the in situ gel-forming delivery systems was 2% (w/w) and that for Pluronic solution was 14% (w/w). The mixture of 0.1% alginate and 14% Pluronic solutions showed a significant increase in gel strength in the physiological condition; this gel mixture was also found to be free flowing at pH 4.0 and 25 °C. Both in vitro release and in vivo pharmacological studies indicated that the alginate/Pluronic solution retained pilocarpine better than the alginate or Pluronic solutions alone. The results demonstrated that the alginate/Pluronic mixture can be used as an in situ gelling vehicle to increase ocular bioavailability.
ISSN:1525-7797
1526-4602
DOI:10.1021/bm0496965