Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity

Dendritic cells (DCs) consist of a heterogeneous collection of subsets, many with unique phenotypic and functional characteristics. Although certain subsets migrate from peripheral non-lymphoid tissues, there is evidence that antigen presentation can extend to DCs that permanently reside within the...

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Bibliographic Details
Published in:Trends in immunology 2004-12, Vol.25 (12), p.655-658
Main Authors: Carbone, Francis R., Belz, Gabrielle T., Heath, William R.
Format: Article
Language:English
Subjects:
Animals
Antigen Presentation
CD8-Positive T-Lymphocytes - immunology
Cell Movement
Dendritic Cells - classification
Dendritic Cells - cytology
Dendritic Cells - immunology
Herpes Simplex - immunology
Humans
Immune Tolerance
Infections
Langerhans Cells - cytology
Langerhans Cells - immunology
Lymph Nodes - cytology
Lymph Nodes - immunology
Medical research
Migration
Models, Immunological
Population
Wound healing
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Description
Summary:Dendritic cells (DCs) consist of a heterogeneous collection of subsets, many with unique phenotypic and functional characteristics. Although certain subsets migrate from peripheral non-lymphoid tissues, there is evidence that antigen presentation can extend to DCs that permanently reside within the lymph node. This Opinion describes this finding in the context of antigen transfer between migrating and lymphoid-resident DCs in cases of T-cell priming and tolerance induction.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2004.09.013