Peritoneal dialysis for chronic renal failure in a patient with methylmalonic acidaemia

Chronic renal failure is a common complication of methylmalonic acidaemia (MMA). It is usually managed with haemodialysis and renal transplantation. We report the use of continuous cycling peritoneal dialysis (CCPD) for 20 months in a paediatric patient with chronic renal failure due to MMA. This pr...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2009-05, Vol.24 (5), p.1085-1087
Main Authors: Etuwewe, Bemigho, Jones, Caroline A., Mathur, Shipra, Wright, Katherine P., Morris, Andrew A. M.
Format: Article
Language:English
Subjects:
Amino Acid Metabolism, Inborn Errors - metabolism
Amino Acid Metabolism, Inborn Errors - therapy
Brief Report
Humans
Infant
Kidney Failure, Chronic - metabolism
Kidney Failure, Chronic - therapy
Kidney Transplantation
Male
Medicine & Public Health
Methylmalonic Acid - metabolism
Nephrology
Pediatrics
Peritoneal Dialysis
Urology
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Summary:Chronic renal failure is a common complication of methylmalonic acidaemia (MMA). It is usually managed with haemodialysis and renal transplantation. We report the use of continuous cycling peritoneal dialysis (CCPD) for 20 months in a paediatric patient with chronic renal failure due to MMA. This procedure resulted in the elimination of 950 μmol methylmalonate (MM) per day and a fall in the plasma MM concentration from 3.9 to 0.74 mmol/l. As a result of this treatment, the frequency at which this patient was hospitalised was markedly reduced prior to a successful renal transplantation.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-008-1068-7