Investigating the morphology, function and genetics of cytotoxic cells in bony fish

Bony fish (teleosts) possess multiple cytotoxic cell lineages that recognize and destroy virally infected and transformed cells. In general, these lineages parallel their functional equivalents in mammals and include neutrophilic granulocytes, macrophages, cytotoxic T lymphocytes (CTL) and natural k...

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Bibliographic Details
Published in:Comparative Biochemistry and Physiology, Part C Part C, 2004-07, Vol.138 (3), p.271-280
Main Author: Yoder, Jeffrey A.
Format: Article
Language:English
Subjects:
Animals
C-type lectin
Cichlidae
Cytotoxic T lymphocyte
Cytotoxicity
Cytotoxicity, Immunologic - immunology
Fishes - genetics
Fishes - immunology
Freshwater
Humans
Killer Cells, Natural - cytology
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Macrophage
Macrophages - cytology
Macrophages - immunology
Natural killer cell
Neutrophil
Neutrophils - cytology
Neutrophils - immunology
Non-specific cytotoxic cells
Novel immune-type receptors
T-Lymphocytes, Cytotoxic - cytology
T-Lymphocytes, Cytotoxic - immunology
Teleostei
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Summary:Bony fish (teleosts) possess multiple cytotoxic cell lineages that recognize and destroy virally infected and transformed cells. In general, these lineages parallel their functional equivalents in mammals and include neutrophilic granulocytes, macrophages, cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. These four cell types have been morphologically identified in multiple fish species but only limited information is available about their function. In contrast, much work has gone into examining the function of a fifth cytotoxic cell lineage, termed nonspecific cytotoxic cells (NCC), that has been referred to as the bony fish equivalent of NK cells. However, evidence suggesting that NCC do not represent the NK lineage has come through the development of multiple cytotoxic catfish cell lines that are morphologically and functionally similar to human NK cells and are distinct from NCC. In addition to characterizing cytotoxic cells from fish, recent work has identified the novel immune-type receptors (NITR) and cichlid killer leukocyte receptors (cKLR) that are structurally related to mammalian NK receptors and likely play a role in cytotoxic function in fish. This review summarizes the morphological and functional evidence for cytotoxic cells within bony fish and discusses future directions for examining cytotoxicity through genomics and transgenics.
ISSN:1532-0456
1878-1659
DOI:10.1016/j.cca.2004.03.008