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Prediagnostic Levels of Serum Micronutrients in Relation to Risk of Gastric Cancer in Shanghai, China
Data on blood levels of specific carotenoids and vitamins in relation to gastric cancer are scarce. Little is known about the relationship between prediagnostic serum levels of carotenoids other than β-carotene and risk of gastric cancer especially in non-Western populations. Prediagnostic serum con...
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| Published in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2004-11, Vol.13 (11), p.1772-1780 |
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| container_issue | 11 |
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| container_title | Cancer epidemiology, biomarkers & prevention |
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| creator | YUAN, Jian-Min ROSS, Ronald K GAO, Yu-Tang QU, Yong-Hua CHU, Xin-Di YU, Mimi C |
| description | Data on blood levels of specific carotenoids and vitamins in relation to gastric cancer are scarce. Little is known about
the relationship between prediagnostic serum levels of carotenoids other than β-carotene and risk of gastric cancer especially
in non-Western populations. Prediagnostic serum concentrations of α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein/zeaxanthin,
retinol, α-tocopherol, γ-tocopherol, and vitamin C were determined on 191 cases and 570 matched controls within a cohort of
18,244 middle-aged or older men in Shanghai, China, with a follow-up of 12 years. High serum levels of α-carotene, β-carotene,
and lycopene were significantly associated with reduced risk of developing gastric cancer (all P s for trend ≤ 0.05); the odds ratios (95% confidence intervals) for the highest versus the lowest quartile of α-carotene,
β-carotene, and lycopene were 0.38 (0.13-1.11), 0.54 (0.32-0.89), and 0.55 (0.30-1.00), respectively. Increased serum level
of vitamin C was significantly associated with reduced risk of gastric cancer among men who neither smoked cigarettes over
lifetime nor consumed ≥3 drinks of alcohol per day; the odds ratios (95% confidence intervals) for the second, third, and
fourth quartile categories were 0.69 (0.28-1.70), 0.36 (0.14-0.94), and 0.39 (0.15-0.98), respectively, compared with the
lowest quartile of vitamin C ( P for trend = 0.02). There were no statistically significant relationships of serum levels of β-cryptoxanthin, lutein/zeaxanthin,
retinol, α-tocopherol, and γ-tocopherol with gastric cancer risk. The present study implicates that dietary carotenes, lycopene,
and vitamin C are potential chemopreventive agents for gastric cancer in humans. |
| doi_str_mv | 10.1158/1055-9965.1772.13.11 |
| format | article |
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the relationship between prediagnostic serum levels of carotenoids other than β-carotene and risk of gastric cancer especially
in non-Western populations. Prediagnostic serum concentrations of α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein/zeaxanthin,
retinol, α-tocopherol, γ-tocopherol, and vitamin C were determined on 191 cases and 570 matched controls within a cohort of
18,244 middle-aged or older men in Shanghai, China, with a follow-up of 12 years. High serum levels of α-carotene, β-carotene,
and lycopene were significantly associated with reduced risk of developing gastric cancer (all P s for trend ≤ 0.05); the odds ratios (95% confidence intervals) for the highest versus the lowest quartile of α-carotene,
β-carotene, and lycopene were 0.38 (0.13-1.11), 0.54 (0.32-0.89), and 0.55 (0.30-1.00), respectively. Increased serum level
of vitamin C was significantly associated with reduced risk of gastric cancer among men who neither smoked cigarettes over
lifetime nor consumed ≥3 drinks of alcohol per day; the odds ratios (95% confidence intervals) for the second, third, and
fourth quartile categories were 0.69 (0.28-1.70), 0.36 (0.14-0.94), and 0.39 (0.15-0.98), respectively, compared with the
lowest quartile of vitamin C ( P for trend = 0.02). There were no statistically significant relationships of serum levels of β-cryptoxanthin, lutein/zeaxanthin,
retinol, α-tocopherol, and γ-tocopherol with gastric cancer risk. The present study implicates that dietary carotenes, lycopene,
and vitamin C are potential chemopreventive agents for gastric cancer in humans.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.1772.13.11</identifier><identifier>PMID: 15533906</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Alcohol Drinking ; Antioxidants - metabolism ; Ascorbic Acid - blood ; Biological and medical sciences ; Carotenoids - blood ; Case-Control Studies ; China - epidemiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Male ; Medical sciences ; Micronutrients - blood ; Middle Aged ; Risk Factors ; Smoking ; Stomach Neoplasms - blood ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - epidemiology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tocopherols - blood ; Tropical medicine ; Tumors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2004-11, Vol.13 (11), p.1772-1780</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-edec196e023698aa402fd22a9e3f2b40506eeda8a964ae2ff32012595b849f993</citedby><cites>FETCH-LOGICAL-c413t-edec196e023698aa402fd22a9e3f2b40506eeda8a964ae2ff32012595b849f993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16278043$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15533906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YUAN, Jian-Min</creatorcontrib><creatorcontrib>ROSS, Ronald K</creatorcontrib><creatorcontrib>GAO, Yu-Tang</creatorcontrib><creatorcontrib>QU, Yong-Hua</creatorcontrib><creatorcontrib>CHU, Xin-Di</creatorcontrib><creatorcontrib>YU, Mimi C</creatorcontrib><title>Prediagnostic Levels of Serum Micronutrients in Relation to Risk of Gastric Cancer in Shanghai, China</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Data on blood levels of specific carotenoids and vitamins in relation to gastric cancer are scarce. Little is known about
the relationship between prediagnostic serum levels of carotenoids other than β-carotene and risk of gastric cancer especially
in non-Western populations. Prediagnostic serum concentrations of α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein/zeaxanthin,
retinol, α-tocopherol, γ-tocopherol, and vitamin C were determined on 191 cases and 570 matched controls within a cohort of
18,244 middle-aged or older men in Shanghai, China, with a follow-up of 12 years. High serum levels of α-carotene, β-carotene,
and lycopene were significantly associated with reduced risk of developing gastric cancer (all P s for trend ≤ 0.05); the odds ratios (95% confidence intervals) for the highest versus the lowest quartile of α-carotene,
β-carotene, and lycopene were 0.38 (0.13-1.11), 0.54 (0.32-0.89), and 0.55 (0.30-1.00), respectively. Increased serum level
of vitamin C was significantly associated with reduced risk of gastric cancer among men who neither smoked cigarettes over
lifetime nor consumed ≥3 drinks of alcohol per day; the odds ratios (95% confidence intervals) for the second, third, and
fourth quartile categories were 0.69 (0.28-1.70), 0.36 (0.14-0.94), and 0.39 (0.15-0.98), respectively, compared with the
lowest quartile of vitamin C ( P for trend = 0.02). There were no statistically significant relationships of serum levels of β-cryptoxanthin, lutein/zeaxanthin,
retinol, α-tocopherol, and γ-tocopherol with gastric cancer risk. The present study implicates that dietary carotenes, lycopene,
and vitamin C are potential chemopreventive agents for gastric cancer in humans.</description><subject>Alcohol Drinking</subject><subject>Antioxidants - metabolism</subject><subject>Ascorbic Acid - blood</subject><subject>Biological and medical sciences</subject><subject>Carotenoids - blood</subject><subject>Case-Control Studies</subject><subject>China - epidemiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Micronutrients - blood</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Smoking</subject><subject>Stomach Neoplasms - blood</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - epidemiology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tocopherols - blood</subject><subject>Tropical medicine</subject><subject>Tumors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNpFkFtv1DAQRi0Eohf4Bwj5hUpIZPElduJHtCoFaRGohWdr1hlvDFmn2AkV_75Od6s-zWh0vhnNIeQNZyvOVfuRM6UqY7Ra8aYRKy7L-Bk55Uq2VdMo9bz0j8gJOcv5N2OsMUq9JCdcKSkN06cEfyTsAuzimKfg6Ab_4ZDp6OkNpnlPvwWXxjhPKWCcMg2RXuMAUxgjnUZ6HfKfhb2CXAhH1xAdpoW66SHueggf6LoPEV6RFx6GjK-P9Zz8-nz5c_2l2ny_-rr-tKlczeVUYYeOG41MSG1agJoJ3wkBBqUX25opphE7aMHoGlB4LwXjQhm1bWvjjZHn5OKw9zaNf2fMk92H7HAYIOI4Z6sbprk0ooD1ASzv5ZzQ29sU9pD-W87sotcu7uzizi56LZdlXGJvj_vn7R67p9DRZwHeHQHIDgafipGQnzgtmpbVsnDvD1wfdv1dSGjdg7uEGSG5_nDv4bS8B8B6kJo</recordid><startdate>20041101</startdate><enddate>20041101</enddate><creator>YUAN, Jian-Min</creator><creator>ROSS, Ronald K</creator><creator>GAO, Yu-Tang</creator><creator>QU, Yong-Hua</creator><creator>CHU, Xin-Di</creator><creator>YU, Mimi C</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041101</creationdate><title>Prediagnostic Levels of Serum Micronutrients in Relation to Risk of Gastric Cancer in Shanghai, China</title><author>YUAN, Jian-Min ; ROSS, Ronald K ; GAO, Yu-Tang ; QU, Yong-Hua ; CHU, Xin-Di ; YU, Mimi C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-edec196e023698aa402fd22a9e3f2b40506eeda8a964ae2ff32012595b849f993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Alcohol Drinking</topic><topic>Antioxidants - metabolism</topic><topic>Ascorbic Acid - blood</topic><topic>Biological and medical sciences</topic><topic>Carotenoids - blood</topic><topic>Case-Control Studies</topic><topic>China - epidemiology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Micronutrients - blood</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Smoking</topic><topic>Stomach Neoplasms - blood</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - epidemiology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tocopherols - blood</topic><topic>Tropical medicine</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YUAN, Jian-Min</creatorcontrib><creatorcontrib>ROSS, Ronald K</creatorcontrib><creatorcontrib>GAO, Yu-Tang</creatorcontrib><creatorcontrib>QU, Yong-Hua</creatorcontrib><creatorcontrib>CHU, Xin-Di</creatorcontrib><creatorcontrib>YU, Mimi C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YUAN, Jian-Min</au><au>ROSS, Ronald K</au><au>GAO, Yu-Tang</au><au>QU, Yong-Hua</au><au>CHU, Xin-Di</au><au>YU, Mimi C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediagnostic Levels of Serum Micronutrients in Relation to Risk of Gastric Cancer in Shanghai, China</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2004-11-01</date><risdate>2004</risdate><volume>13</volume><issue>11</issue><spage>1772</spage><epage>1780</epage><pages>1772-1780</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Data on blood levels of specific carotenoids and vitamins in relation to gastric cancer are scarce. Little is known about
the relationship between prediagnostic serum levels of carotenoids other than β-carotene and risk of gastric cancer especially
in non-Western populations. Prediagnostic serum concentrations of α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein/zeaxanthin,
retinol, α-tocopherol, γ-tocopherol, and vitamin C were determined on 191 cases and 570 matched controls within a cohort of
18,244 middle-aged or older men in Shanghai, China, with a follow-up of 12 years. High serum levels of α-carotene, β-carotene,
and lycopene were significantly associated with reduced risk of developing gastric cancer (all P s for trend ≤ 0.05); the odds ratios (95% confidence intervals) for the highest versus the lowest quartile of α-carotene,
β-carotene, and lycopene were 0.38 (0.13-1.11), 0.54 (0.32-0.89), and 0.55 (0.30-1.00), respectively. Increased serum level
of vitamin C was significantly associated with reduced risk of gastric cancer among men who neither smoked cigarettes over
lifetime nor consumed ≥3 drinks of alcohol per day; the odds ratios (95% confidence intervals) for the second, third, and
fourth quartile categories were 0.69 (0.28-1.70), 0.36 (0.14-0.94), and 0.39 (0.15-0.98), respectively, compared with the
lowest quartile of vitamin C ( P for trend = 0.02). There were no statistically significant relationships of serum levels of β-cryptoxanthin, lutein/zeaxanthin,
retinol, α-tocopherol, and γ-tocopherol with gastric cancer risk. The present study implicates that dietary carotenes, lycopene,
and vitamin C are potential chemopreventive agents for gastric cancer in humans.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>15533906</pmid><doi>10.1158/1055-9965.1772.13.11</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 2004-11, Vol.13 (11), p.1772-1780 |
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| source | EZB Electronic Journals Library |
| subjects | Alcohol Drinking Antioxidants - metabolism Ascorbic Acid - blood Biological and medical sciences Carotenoids - blood Case-Control Studies China - epidemiology Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Micronutrients - blood Middle Aged Risk Factors Smoking Stomach Neoplasms - blood Stomach Neoplasms - diagnosis Stomach Neoplasms - epidemiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tocopherols - blood Tropical medicine Tumors |
| title | Prediagnostic Levels of Serum Micronutrients in Relation to Risk of Gastric Cancer in Shanghai, China |
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