Association between LDL particle size and postprandial increase of remnant-like particles in Japanese type 2 diabetic patients

Small, dense LDL, as well as chylomicron- and VLDL-remnant lipoproteins, are known to be important risk factors for coronary heart disease in patients with type 2 diabetes mellitus. The aim of this study was to clarify the relationship between LDL particle size and postprandial remnant lipoprotein l...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2004-12, Vol.66 (3), p.245-252
Main Authors: Takayanagi, Naoko, Onuma, Tomio, Kato, Shinobu, Nishiyama, Kyoko, Nomiyama, Takashi, Kawamori, Ryuzo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Asian Continental Ancestry Group
Cholesterol - blood
Dense LDL
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - ethnology
Female
Humans
Lipoproteins - blood
Lipoproteins, LDL - blood
Lipoproteins, LDL - chemistry
Male
Middle Aged
Particle Size
Postprandial lipoprotein metabolism
Postprandial Period
Remnant lipoproteins
Remnant-like particles (RLP)
Small
Triglycerides - blood
Type 2 diabetes mellitus
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Summary:Small, dense LDL, as well as chylomicron- and VLDL-remnant lipoproteins, are known to be important risk factors for coronary heart disease in patients with type 2 diabetes mellitus. The aim of this study was to clarify the relationship between LDL particle size and postprandial remnant lipoprotein levels in Japanese type 2 diabetic patients Forty-six patients with type 2 diabetes mellitus were divided into tertiles according to LDL particle size. The peak LDL particle diameter was 26.85 nm in tertile 3. After a test meal, tertile 1 had a significantly greater increment of triglycerides (TG), remnant-like particle (RLP)-TG, and RLP-cholesterol (RLP-C) than tertiles 2 and 3. There was a negative correlation between LDL particle size and the postprandial increases of TG, RLP-TG, and RLP-C. These results indicate that smaller sized LDL particles may be a marker of fasting state for an exaggerated postprandial increase of remnant lipoproteins as well as an increase of TG-rich lipoproteins.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2004.04.002