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On-line assay of the S-enantiomers of enalapril, ramipril and pentopril using a sequential injection analysis/amperometric biosensor system

A sequential injection analysis/amperometric biosensor system is proposed for the enantioselective analysis of the S-enantiomer of enalapril, ramipril and pentopril. The amperometric biosensor used as detector in the sequential injection analysis was designed by immobilization of l-amino acid oxidas...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2004-11, Vol.36 (4), p.889-892
Main Authors: Stefan, Raluca-Ioana, Staden, Jacobus F. van, Bala, Camelia, Aboul-Enein, Hassan Y.
Format: Article
Language:English
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Summary:A sequential injection analysis/amperometric biosensor system is proposed for the enantioselective analysis of the S-enantiomer of enalapril, ramipril and pentopril. The amperometric biosensor used as detector in the sequential injection analysis was designed by immobilization of l-amino acid oxidase in carbon paste. The proposed SIA system can be utilized reliably for the enantioanalysis of the S-enantiomer from the raw materials as well as from their pharmaceutical formulations, with a rate of 75 samples per hour and R.S.D. values better than 0.1% ( n = 10).
ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2004.08.017