First reported pediatric case of systemic lupus erythematosus associated with prolactinoma

There is much interest in the possibility that prolactin influences disease activity in systemic lupus erythematosus (SLE). We present the first reported pediatric case of prolactinoma associated with SLE, in a 13‐year‐old white female. The diagnosis of SLE was based on the presence of arthritis, an...

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Bibliographic Details
Published in:Arthritis and rheumatism 2004-11, Vol.50 (11), p.3616-3618
Main Author: Reuman, Peter D.
Format: Article
Language:English
Subjects:
Adolescent
Arthritis - etiology
Biological and medical sciences
Bromocriptine - therapeutic use
Diseases of the osteoarticular system
Female
Hormone Antagonists - therapeutic use
Humans
Inflammation Mediators - blood
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - drug therapy
Medical sciences
Pituitary Neoplasms - complications
Pituitary Neoplasms - surgery
Prolactin - blood
Prolactinoma - complications
Prolactinoma - drug therapy
Prolactinoma - surgery
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Treatment Outcome
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Summary:There is much interest in the possibility that prolactin influences disease activity in systemic lupus erythematosus (SLE). We present the first reported pediatric case of prolactinoma associated with SLE, in a 13‐year‐old white female. The diagnosis of SLE was based on the presence of arthritis, antinuclear antibodies, and double‐stranded DNA, and a chest radiograph showing pleural fluid. The diagnosis of pituitary prolactinoma was based on the histologic features and the presence of amenorrhea, galactorrhea, and an elevated serum prolactin level. Neurosurgical resection and medical therapy with bromocriptine mesylate were independently associated with decreased prolactin levels, loss of arthritis, and reduced levels of inflammatory mediators.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.20751