Structure and stability of columnar cyclomaltohexaose (α-cyclodextrin) hydrate

[Display omitted] Rapid recrystallization of cyclomaltohexaose (α-cyclodextrin, α-CD) from aqueous solution resulted in formation of the columnar crystal structure of α-CD containing only water as the guest molecule. Complementary water vapor sorption and wide-angle X-ray diffractometry (WAXD) exper...

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Bibliographic Details
Published in:Carbohydrate research 2004-12, Vol.339 (17), p.2805-2810
Main Authors: Hunt, Marcus A., Rusa, Cristian C., Tonelli, Alan E., Balik, C. Maurice
Format: Article
Language:English
Subjects:
alpha-Cyclodextrins - chemistry
Carbohydrate Conformation
carbohydrate structure
crystal structure
Crystallography, X-Ray
cyclodextrins
Cyclomaltohexaose
Models, Molecular
Phase transformation
phase transition
Water - chemistry
water activity
Water vapor sorption
Wide-angle X-ray diffraction
X-ray diffraction
α-Cyclodextrin
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Summary:[Display omitted] Rapid recrystallization of cyclomaltohexaose (α-cyclodextrin, α-CD) from aqueous solution resulted in formation of the columnar crystal structure of α-CD containing only water as the guest molecule. Complementary water vapor sorption and wide-angle X-ray diffractometry (WAXD) experiments were performed on the α-CD columnar structure to elucidate the crystal structure present at varying sorption levels. Equilibrium isothermal water vapor sorption experiments at 40 °C revealed that the α-CD columnar structure is unstable above a water activity of approximately 0.67. This was confirmed by WAXD diffractograms collected over time, which further revealed that α-CD columnar structure undergoes a phase transformation to the cage structure after approximately 0.25 h at 40 °C and a water activity of 1.0.
ISSN:0008-6215
1873-426X
DOI:10.1016/j.carres.2004.09.012