Mechanistic actions of the risks and adverse events associated with vaccine administration

Vaccine-preventable disease levels in the United States are at or near record lows. Most parents today have never seen a case of diphtheria, measles, or other once commonly encountered infectious diseases now preventable by vaccine administration. As a result, some parents wonder why their children...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2004-11, Vol.114 (5), p.1010-1020
Main Authors: Moylett, Edina H., Hanson, I. Celine
Format: Article
Language:English
Subjects:
adjuvants
Aluminum
Autoimmune diseases
Biological and medical sciences
Children & youth
Diabetes
Diphtheria
Disease
egg sensitivity
Fever
Fundamental and applied biological sciences. Psychology
Fundamental immunology
gelatin
Health maintenance organizations
Hepatitis B Vaccines - adverse effects
HMOs
Humans
Immunopathology
Influenza
Influenza Vaccines - adverse effects
live viral vaccine
Measles-Mumps-Rubella Vaccine - adverse effects
Medical sciences
Mortality
Poliovirus Vaccine, Inactivated - adverse effects
preservative
Risk
Safety
Tetanus
thimerosal
Toxoid
Tropical diseases
vaccine adverse events
vaccine allergy
Vaccines
Vaccines - adverse effects
Vaccines, Inactivated - adverse effects
Viruses
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Summary:Vaccine-preventable disease levels in the United States are at or near record lows. Most parents today have never seen a case of diphtheria, measles, or other once commonly encountered infectious diseases now preventable by vaccine administration. As a result, some parents wonder why their children must receive shots for diseases that do not seem to exist. Myths and misinformation about vaccine safety abound and can confuse parents who are trying to make sound decisions about their children's health care. However, we cannot take continued high immunization coverage levels for granted. A successful vaccination program, like a successful society, depends on the cooperation of every individual to ensure the good of all. This review outlines for clinical allergists-immunologists the molecular basis for the risks and adverse events associated with vaccine administration so that they can be better informed as experts on vaccine-associated adverse reactions.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2004.09.007