Vascular factors in dementia: an overview

Alzheimer's disease and cerebrovascular disease are two illnesses common to the elderly. Conventional wisdom has sought to separately describe and treat these two diseases. Accumulating evidence, however, shows that cerebrovascular risk factors may cause asymptomatic brain injury, share genetic...

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Bibliographic Details
Published in:Journal of the neurological sciences 2004-11, Vol.226 (1), p.19-23
Main Author: DeCarli, Charles
Format: Article
Language:English
Subjects:
Aged
Alzheimer disease
Alzheimer Disease - pathology
Biological and medical sciences
Brain - pathology
Cerebrovascular Circulation - physiology
Cerebrovascular disease
Cerebrovascular Disorders - pathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia
Dementia, Vascular - pathology
Disease Progression
Humans
Medical sciences
Neurology
Vascular diseases and vascular malformations of the nervous system
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Description
Summary:Alzheimer's disease and cerebrovascular disease are two illnesses common to the elderly. Conventional wisdom has sought to separately describe and treat these two diseases. Accumulating evidence, however, shows that cerebrovascular risk factors may cause asymptomatic brain injury, share genetic risk with Alzheimer's disease and possibly accelerate the Alzheimer's process. Such evidence suggests that these two diseases may act additively or synergistically to cause clinical dementia. This review focuses on evolving data that support this hypothesis.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2004.09.005