The role of oxidative damage and stress in aging

The Free Radical/Oxidative Stress Theory of Aging, which was first proposed in 1956, is currently one of the most popular explanations for how aging occurs at the biochemical/molecular level. However, most of the evidence in support of this theory is correlative, e.g., oxidative damage to various bi...

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Bibliographic Details
Published in:Mechanisms of ageing and development 2004-10, Vol.125 (10), p.811-826
Main Authors: Bokov, Alex, Chaudhuri, Asish, Richardson, Arlan
Format: Article
Language:English
Subjects:
Aging - genetics
Aging - physiology
Animals
Antioxidants
Free radicals
Free Radicals - metabolism
Humans
Oxidative damage
Oxidative stress
Oxidative Stress - genetics
Oxidative Stress - physiology
Reactive Oxygen Species - metabolism
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Summary:The Free Radical/Oxidative Stress Theory of Aging, which was first proposed in 1956, is currently one of the most popular explanations for how aging occurs at the biochemical/molecular level. However, most of the evidence in support of this theory is correlative, e.g., oxidative damage to various biomolecules increases with age, and caloric restriction, which increases life span and retards aging, reduces the age-related increase in oxidative damage to biomolecules. The most direct test of the Free Radical/Oxidative Stress Theory of Aging is to specifically alter the age-related increase in oxidative damage and determine how this alteration affects life span. For the first time, investigators can use genetically altered animals to test directly the role of oxidative damage in aging. In this manuscript, we critically review the past research in this area and discuss potential future research directions in testing the Free Radical/Oxidative Theory of Aging.
ISSN:0047-6374
1872-6216
DOI:10.1016/j.mad.2004.07.009