Short-term habituation of the intracranially recorded auditory evoked potentials P50 and N100

At an interstimulus interval (ISI) of 500-ms stimulus repetition leads to a strong decrease in cortical response. The functional foundation of this response suppression (or sensory gating) is yet not fully understood. Experiments on short-term habituation using the same stimulus material as sensory...

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Bibliographic Details
Published in:Neuroscience letters 2004-12, Vol.372 (3), p.245-249
Main Authors: Rosburg, Timm, Trautner, Peter, Korzyukov, Oleg A., Boutros, Nashaat N., Schaller, Carlo, Elger, Christian Erich, Kurthen, Martin
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Adolescent
Adult
Auditory cortex
Auditory Cortex - physiology
Auditory evoked potentials
Biological and medical sciences
Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation
Electrocorticography
Electrodes
Electroencephalography
Electrophysiology
Evoked Potentials, Auditory - physiology
Female
Fundamental and applied biological sciences. Psychology
Habituation
Habituation, Psychophysiologic - physiology
Humans
Male
Middle Aged
N100
P50
Pitch Perception - physiology
Sensory gating
Vertebrates: nervous system and sense organs
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Summary:At an interstimulus interval (ISI) of 500-ms stimulus repetition leads to a strong decrease in cortical response. The functional foundation of this response suppression (or sensory gating) is yet not fully understood. Experiments on short-term habituation using the same stimulus material as sensory gating experiments and same ISI might help to elucidate the mechanisms behind the P50 suppression. Event-related potentials were recorded intracranially in epileptic patients undergoing presurgical evaluation with subdural and depth electrodes. Stimulus material consisted of trains of six clicks, with the last stimulus deviating in pitch and duration. P50 and N100 were calculated for each stimulus in the train separately and compared by analysis of variance (ANOVA). A highly significant amplitude reduction was found from the 1st to 2nd stimulus for both P50 and N100. From the 2nd to 5th stimulus no further amplitude decrease was observable. The deviating 6th stimulus led to a response recovery of both components, but the P50 elicited by the 6th stimulus was still smaller than the P50 of the 1st stimulus. Current results indicate that the P50 suppression as investigated in sensory gating experiments seems to be completed after the 2nd stimulus.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2004.09.047