Characterization of antibodies to PspA and PsaA in adults over 50 years of age with invasive pneumococcal disease

We characterized antibody responses to two Streptococcus pneumoniae surface proteins, PspA and PsaA, in 14 adults over 50 years of age hospitalized with invasive pneumococcal disease (IPD), and in two groups of age-matched controls (18 patients with invasive disease due to other microorganisms and 3...

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Bibliographic Details
Published in:Vaccine 2004-12, Vol.23 (6), p.789-793
Main Authors: Baril, Laurence, Briles, David E., Crozier, Pierre, King, Janice, Punar, Metin, Hollingshead, Susan K., McCormick, Joseph B.
Format: Article
Language:English
Subjects:
Adhesins, Bacterial
Adult
Age
Aged
Amino acids
Antibodies, Bacterial - biosynthesis
Antibody response
Antigens
Applied microbiology
Bacterial Capsules - immunology
Bacterial Proteins - immunology
Bacteriology
Biological and medical sciences
Confidence intervals
Disease
Fundamental and applied biological sciences. Psychology
HIV
Hospitalization
Human immunodeficiency virus
Humans
Lipoproteins - immunology
Male
Membrane Transport Proteins - immunology
Microbiology
Microorganisms
Middle Aged
Miscellaneous
Mortality
Pneumococcal Vaccines - administration & dosage
Pneumococcal Vaccines - immunology
Pneumonia
Pneumonia, Pneumococcal - immunology
Proteins
PsaA
PspA
Streptococcus infections
Streptococcus pneumoniae
Streptococcus pneumoniae - immunology
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:We characterized antibody responses to two Streptococcus pneumoniae surface proteins, PspA and PsaA, in 14 adults over 50 years of age hospitalized with invasive pneumococcal disease (IPD), and in two groups of age-matched controls (18 patients with invasive disease due to other microorganisms and 35 patients hospitalized for non infectious conditions). All patients with IPD and all control subjects had detectable antibodies to both proteins on hospital admission. Three weeks later, the geometric mean concentrations of antibodies to PspA and PsaA in IPD patients were respectively 10 and 25 times higher than on admission. In contrast, acute and convalescent antibody levels were similar in control patients with invasive diseases due to other microorganisms.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2004.07.033