Value of noncontact mapping for identifying left ventricular scar in an ovine model

We assessed the hypothesis that "virtual electrograms" from a noncontact mapping system (EnSite 3000) could be used to localize myocardial scar. Myocardial infarctions were induced in sheep by inflating an angioplasty balloon in the left anterior descending coronary artery for 3 hours. Sca...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2004-11, Vol.110 (20), p.3175-3180
Main Authors: Thiagalingam, Aravinda, Wallace, Elisabeth M, Campbell, Craig R, Boyd, Anita C, Eipper, Vicki E, Byth, Karen, Ross, David L, Kovoor, Pramesh
Format: Article
Language:English
Subjects:
Animals
Cardiac Catheterization - instrumentation
Cardiac Catheterization - methods
Cardiac Pacing, Artificial
Catheterization - adverse effects
Catheterization - instrumentation
Cicatrix - etiology
Cicatrix - pathology
Electrophysiology - instrumentation
Electrophysiology - methods
Equipment Design
Heart Ventricles - pathology
Imaging, Three-Dimensional
Myocardial Infarction - etiology
Myocardial Infarction - pathology
Sheep
User-Computer Interface
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Summary:We assessed the hypothesis that "virtual electrograms" from a noncontact mapping system (EnSite 3000) could be used to localize myocardial scar. Myocardial infarctions were induced in sheep by inflating an angioplasty balloon in the left anterior descending coronary artery for 3 hours. Scar mapping was performed on 8 sheep without inducible ventricular tachycardia by use of the noncontact mapping system and a 256-channel contact mapping system. Transmural mapping needles were inserted into myocardial regions that were (1) scarred, (2) peripheral to the scar, and (3) distant from the scar. Unipolar electrograms were exported from both systems and analyzed on a personal computer workstation. The percentage of myocardial scarring at each needle site was assessed histologically. Pearson's correlation was used to assess the degree of association between various electrogram characteristics and the presence of myocardial scarring. The only noncontact electrogram characteristic that showed any association with the presence of myocardial scarring was the negative slope duration (contact, r=0.62, P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000147234.82755.90