The Metabolic Syndrome in Obese Postmenopausal Women: Relationship to Body Composition, Visceral Fat, and Inflammation

The purpose of this study was to investigate whether aerobic fitness, body composition, body fat distribution, and inflammation are different in obese postmenopausal women with and without the metabolic syndrome (MS), and whether the severity of MS is associated with these characteristics. Fifty-eig...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2004-11, Vol.89 (11), p.5517-5522
Main Authors: You, Tongjian, Ryan, Alice S., Nicklas, Barbara J.
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Biological and medical sciences
Body Composition
Body Mass Index
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Humans
Inflammation - complications
Medical sciences
Metabolic Syndrome - complications
Metabolic Syndrome - etiology
Middle Aged
Obesity - complications
Postmenopause - metabolism
Receptors, Tumor Necrosis Factor, Type I - blood
Vertebrates: endocrinology
Viscera
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Summary:The purpose of this study was to investigate whether aerobic fitness, body composition, body fat distribution, and inflammation are different in obese postmenopausal women with and without the metabolic syndrome (MS), and whether the severity of MS is associated with these characteristics. Fifty-eight women (age, 59 ± 1 yr; body mass index, 33.0 ± 0.6 kg/m2) completed testing of maximal aerobic capacity, body composition (fat mass, lean mass, and percent body fat), body fat distribution (sc and visceral fat areas, and regional adipocyte sizes), and inflammation (C-reactive protein, IL-6, and TNF-α, and their soluble receptors). Lean mass (44.4 ± 0.9 vs. 41.2 ± 0.9 kg; P < 0.05), visceral fat area (180 ± 10 vs. 135 ± 7 cm2; P < 0.001), and plasma soluble TNF receptor 1 (sTNFR1; 860 ± 25 vs. 765 ± 42 pg/ml; P < 0.05) were higher in women with the MS (n = 27) than in those without the MS (n = 31). The number of MS components was directly related to weight, body mass index, fat mass, lean mass, visceral fat area, and plasma sTNFR1. We conclude that obese older women with the MS are characterized by high lean mass, high visceral fat, and elevated sTNFR1, and the severity of the MS is associated with body composition, visceral adiposity, and inflammation.
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2004-0480