The Role of Inter-Alpha Inhibitor Proteins in the Diagnosis of Neonatal Sepsis

We evaluated Inter-alpha inhibitor proteins (IaIp) as a diagnostic marker in neonatal sepsis. Samples were collected from 573 neonates who were examined for suspected sepsis. IaIp level was significantly lower in the septic group (121 ± 71 mg/L) than in the non-septic group (322 ± 91 mg/L). The opti...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of pediatrics 2009-04, Vol.154 (4), p.620-622.e1
Main Authors: Chaaban, Hala, MD, Singh, Kultar, MD, Huang, Juliza, Siryaporn, Ed, Lim, Yow-Pin, MD, PhD, Padbury, James F., MD
Format: Article
Language:English
Subjects:
Alpha-Globulins - metabolism
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Biomarkers - blood
Case-Control Studies
Female
General aspects
Human bacterial diseases
Humans
Infant, Newborn
Infectious diseases
Male
Medical sciences
Pediatrics
Reproducibility of Results
Sensitivity and Specificity
Sepsis - diagnosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We evaluated Inter-alpha inhibitor proteins (IaIp) as a diagnostic marker in neonatal sepsis. Samples were collected from 573 neonates who were examined for suspected sepsis. IaIp level was significantly lower in the septic group (121 ± 71 mg/L) than in the non-septic group (322 ± 91 mg/L). The optimal cutoff value with the receiver operating characteristic curve was ≤177 mg/L (sensitivity, 89.5%; specificity, 99%; positive predictive value, 95%; negative predictive value, 98%) with area under the curve of 0.94. IaIp is a more reliable diagnostic marker for neonatal sepsis than other available tests.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2008.10.008