Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles

1,3,4-Oxadiazole and 1,2,4-triazole derivatives were prepared as anticonvulsant agents. Pharmacological evaluation was performed on the synthesized compounds. A series of new 2-substituted-5-[2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles has been synthesized and screened for their anticonvulsant acti...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2004-12, Vol.14 (24), p.6057-6059
Main Authors: Almasirad, Ali, Tabatabai, Sayyed A., Faizi, Mehrdad, Kebriaeezadeh, Abbas, Mehrabi, Nazila, Dalvandi, Afshin, Shafiee, Abbas
Format: Article
Language:English
Subjects:
Anticonvulsant
Anticonvulsants - chemical synthesis
Anticonvulsants - pharmacology
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Drug Evaluation, Preclinical
Medical sciences
MES
Molecular Structure
Neuropharmacology
Oxadiazoles - chemical synthesis
Oxadiazoles - pharmacology
Pharmacology. Drug treatments
PTZ
Structure-Activity Relationship
Substituted 1,3,4-oxadiazoles
Triazoles - chemical synthesis
Triazoles - pharmacology
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Summary:1,3,4-Oxadiazole and 1,2,4-triazole derivatives were prepared as anticonvulsant agents. Pharmacological evaluation was performed on the synthesized compounds. A series of new 2-substituted-5-[2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles has been synthesized and screened for their anticonvulsant activities. Compound 3 shows considerable anticonvulsant activity both in PTZ and MES models. It seems that this effect is mediated by benzodiazepine receptors and other unknown mechanism, respectively.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2004.09.072