The Combination of IMT and Stiffness Parameter β is Highly Associated with Concurrent Coronary Artery Disease in Type 2 Diabetes

• Published in: Journal of Atherosclerosis and Thrombosis 2009, Vol.16(1), pp.33-39
• Main Authors: Lee, Eiko, Emoto, Masanori, Teramura, Megumi, Tsuchikura, Shoko, Ueno, Hiroki, Shinohara, Kayo, Morioka, Tomoaki, Mori, Katsuhito, Koyama, Hidenori, Shoji, Tetsuo, Okuno, Yasuhisa, Inaba, Masaaki, Nishizawa, Yoshiki
• Format: Article
• Language: English
• Subjects: Age Factors; Aged; Carotid atherosclerosis; Coronary artery disease; Coronary Disease - diagnostic imaging; Coronary Disease - etiology; Coronary Vessels - diagnostic imaging; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnostic imaging; Female; Humans; Male; Tunica Intima - diagnostic imaging; Type 2 diabetes; Ultrasonography; Ultrasound
• ISSN: 1340-3478; 1880-3873
• DOI: 10.5551/jat.E605

Aims: The clinical implications of stiffness of the carotid artery (CA) have not been fully clarified in the prediction of coronary artery disease (CAD), although intima-media thickness (IMT) has been established as a surrogate marker. We examined the associations of stiffness parameter β (ST) and IMT with concurrent CAD. Methods: IMT and ST were measured by ultrasound in 439 nondiabetic subjects as a control and 1528 type 2 diabetic subjects (T2DM) with or without CAD in a cross-sectional study. Results: Both IMT and ST significantly increased with age and group category, in the order of control, T2DM without CAD, and T2DM with CAD (p&lt0.001). The area under the curve on ROC analysis of ST for concurrent CAD was comparable to that for IMT. On multivariate logistic regression analysis, High IMT (≥1.30 mm) and High stiffness (≥20.0) had significant odds ratios for concurrent CAD (2.205, p&lt0.001 and 1.548, p&lt0.05, respectively). The group with High IMT and High Stiffness exhibited a stronger multivariate odds ratio (3.115, p=0.0001). Conclusions: ST and IMT are associated with CAD and exhibited significant odds ratios for CAD. Our findings suggest that the combination of IMT and ST is a useful marker of atherosclerosis.