Effect of parenteral selenium administration to sheep on prevalence and recovery from footrot

• Published in: Journal of veterinary internal medicine 2009-03, Vol.23 (2), p.352-358
• Main Authors: Hall, J.A, Bailey, D.P, Thonstad, K.N, Van Saun, R.J
• Format: Article
• Language: English
• Subjects: Animals; Dichelobacter nodosus - growth & development; dietary supplements; disease prevalence; Female; Foot Rot - blood; Foot Rot - drug therapy; Foot Rot - microbiology; Foot Rot - prevention & control; footrot; Gram-Negative Bacterial Infections - drug therapy; Gram-Negative Bacterial Infections - microbiology; Gram-Negative Bacterial Infections - prevention & control; Gram-Negative Bacterial Infections - veterinary; Infectious diseases; Inflammation; Nutrition-trace elements; Ovine; Prevalence; Prospective Studies; selenium; Selenium - administration & dosage; Selenium - blood; Sheep; Sheep Diseases - blood; Sheep Diseases - drug therapy; Sheep Diseases - microbiology; Sheep Diseases - prevention & control
• ISSN: 0891-6640; 1939-1676
• DOI: 10.1111/j.1939-1676.2008.0253.x

Background: Insufficient intake of selenium (Se) is common in many regions, and can contribute to increased susceptibility to and prolonged recovery from infectious diseases. Objective: To determine the effect of Se administration in decreasing the severity and prevalence of footrot in sheep. Animals: Thirty‐eight footrot‐affected and 19 nonaffected sheep from a commercial flock of known high incidence of footrot. Methods: Placebo‐controlled, prospective, 15‐month clinical trial. Footrot‐affected sheep were randomly assigned into 2 groups (n = 19) and injected with either 5 mg Se (footrot [FR]‐Se) or saline (FR‐Sal) at 1‐month intervals for the duration of the study. Unaffected sheep (controls) received no treatment. Sheep feet were examined, trimmed, and scored for footrot with a scale of 0 (no footrot) to 4 (extensive) at 0, 3, 6, 9, and 15 months. Sheep were also bled at time 0 and then at 3, 6, and 15 months to assess whole blood Se concentrations. Results: At time 0, control sheep (255 ± 11 ng/mL) had higher (P < .05) whole blood Se concentrations compared with FR‐Se (205 ± 12 ng/mL) and FR‐Sal (211 ± 14 ng/mL) sheep. By 6 months, FR‐Se sheep (317 ± 9 ng/mL) had whole blood Se concentrations greater (P < .05) than both control (281 ± 14 ng/mL) and FR‐Sal (277 ± 16 ng/mL) sheep. FR‐Se ewes showed a faster decline in highest lesion score at 3 (P= .012) and 6 (P= .0036) months, and a greater decrease in the number of feet with foot score >0 at 6 (P= .020) months compared with FR‐Sal ewes. Sheep with blood Se concentrations