The contribution of cerebrospinal fluid oligoclonal bands to the early diagnosis of multiple sclerosis

• Published in: Multiple sclerosis 2009-04, Vol.15 (4), p.472-478
• Main Authors: Zipoli, V, Hakiki, B, Portaccio, E, Lolli, F, Siracusa, G, Giannini, M, Pantoni, L, Pescini, F, Sorbi, S, Amato, MP
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Biological and medical sciences; Databases, Factual; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Diagnosis, Differential; Disability Evaluation; Early Diagnosis; Female; Follow-Up Studies; Humans; Immunologic Tests - standards; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Multiple Sclerosis - diagnosis; Multiple Sclerosis - immunology; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Neurology; Oligoclonal Bands - immunology; Predictive Value of Tests; Reproducibility of Results; Sensitivity and Specificity; Young Adult
• ISSN: 1352-4585; 1477-0970
• DOI: 10.1177/1352458508100502

Background McDonald Criteria (MDC) have been validated in selected patients at high risk for multiple sclerosis (MS). However, possible overdiagnosis of MS can represent critical issues in less controlled clinical settings. Objective To assess the contribution of oligoclonal bands (OB) to MS diagnosis in current clinical practice. Methods We included all the patients admitted to our Department since 2001 who had undergone diagnostic workup for a possible MS diagnosis, followed up for at least 1 year. We assessed the accuracy of MDC, OB, and two MDC definitions of dissemination in space (DIS-MRI: fulfillment of MRI criteria, DIS-OB: two MRI lesions+OB). Results We included 118 patients (median follow-up 4.0 years). Twenty-eight cases received an alternative diagnosis, whereas none of these presented OB, 43% fulfilled the DIS-MRI criteria. OB were present in 70% of the remaining 90 patients. By the end of the follow-up, 56% of the diagnoses had converted to clinically definite MS and OB showed higher accuracy than DIS-MRI fulfillment (70% vs 58%). Moreover, after 1 year and at the end of the follow-up, DIS-OB yielded a higher Specificity level in comparison with DIS-MRI. Conclusion OB can improve overall diagnostic Accuracy by increasing Specificity and negative predictive value.