Palladium-Catalyzed Borylation of Phenyl Bromides and Application in One-Pot Suzuki−Miyaura Biphenyl Synthesis

The coupling reaction of pinacolborane with various aryl bromides in the presence of a catalytic amount of Pd(OAc)2 together with DPEphos as ligand and Et3N as base provided arylboronates. High yields were obtained in the case of electron-donor substituted aryl bromides. The direct preparation of ar...

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Bibliographic Details
Published in:Organic letters 2004-11, Vol.6 (24), p.4419-4422
Main Authors: Broutin, Pierre-Emmanuel, Čerňa, Igor, Campaniello, Maria, Leroux, Frédéric, Colobert, Françoise
Format: Article
Language:English
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Summary:The coupling reaction of pinacolborane with various aryl bromides in the presence of a catalytic amount of Pd(OAc)2 together with DPEphos as ligand and Et3N as base provided arylboronates. High yields were obtained in the case of electron-donor substituted aryl bromides. The direct preparation of arylboronates allowed the one-pot, two-step synthesis of unsymmetrical biaryls in high yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol048303b