Ruthenium-Catalyzed [2 + 2] Cycloadditions between Bicyclic Alkenes and Alkynyl Halides

Ru-catalyzed [2 + 2] cycloadditions between norbornadiene and alkynyl halides were found to occur in moderate to good yields (32−89%). The presence of the halide moiety greatly enhances the reactivity of the alkyne component in the cycloaddition and can be transformed into a variety of products that...

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Bibliographic Details
Published in:Organic letters 2004-11, Vol.6 (24), p.4543-4546
Main Authors: Villeneuve, Karine, Riddell, Nicole, Jordan, Robert W, Tsui, Gavin C, Tam, William
Format: Article
Language:English
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Summary:Ru-catalyzed [2 + 2] cycloadditions between norbornadiene and alkynyl halides were found to occur in moderate to good yields (32−89%). The presence of the halide moiety greatly enhances the reactivity of the alkyne component in the cycloaddition and can be transformed into a variety of products that are difficult or impossible to obtain via direct cycloaddition.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol048111g