Conversion from Arenes Having a Benzene Ring to Those Having a Picolinic Acid by Simple Growing Cell Reactions Using Escherichia coli that Expressed the Six Bacterial Genes Involved in Biphenyl Catabolism

The comprehensive bioconversion of aromatic compounds with a benzene ring to a picolinic acid was achieved with a recombinant Escherichia coli strain that expressed the six genes involved in biphenyl catabolism, these being the bphA1(2072)A2A3A4 genes encoding the evolved biphenyl dioxygenase, the b...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2004-11, Vol.126 (46), p.15042-15043
Main Authors: SHINDO, Kazutoshi, OSAWA, Ayako, NAKAMURA, Ryoko, KAGIYAMA, Yukiko, SAKUDA, Shohei, SHIZURI, Yoshikazu, FURUKAWA, Kensuke, MISAWA, Norihiko
Format: Article
Language:English
Subjects:
Benzene Derivatives - metabolism
Benzoxazoles - metabolism
Biological and medical sciences
Biphenyl Compounds - metabolism
Dioxygenases - genetics
Dioxygenases - metabolism
Escherichia coli - enzymology
Escherichia coli - genetics
Flavonoids - metabolism
Fundamental and applied biological sciences. Psychology
Indans - metabolism
Iron-Sulfur Proteins - genetics
Iron-Sulfur Proteins - metabolism
Mechanisms. Catalysis. Electron transfer. Models
Molecular biophysics
Oxygenases - genetics
Oxygenases - metabolism
Physical chemistry in biology
Picolinic Acids - metabolism
Quinolines - metabolism
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Summary:The comprehensive bioconversion of aromatic compounds with a benzene ring to a picolinic acid was achieved with a recombinant Escherichia coli strain that expressed the six genes involved in biphenyl catabolism, these being the bphA1(2072)A2A3A4 genes encoding the evolved biphenyl dioxygenase, the bphB gene encoding dihydrodiol dehydrogenase, and the bphC gene encoding catechol 2,3-dioxygenase.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja044850g