Interleukin-6, interleukin-8, and soluble tumor necrosis factor receptor-I in the cord blood as predictors of chronic lung disease in premature infants

• Published in: American journal of obstetrics and gynecology 2004-11, Vol.191 (5), p.1649-1654
• Main Authors: An, Hiromi, Nishimaki, Shigeru, Ohyama, Makiko, Haruki, Atsushi, Naruto, Takuya, Kobayashi, Naoki, Sugai, Toshiyuki, Kobayashi, Yoshinori, Mori, Masaaki, Seki, Kazuo, Yokota, Shumpei
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Case-Control Studies; Chorioamnionitis; Chronic Disease; Chronic lung disease; Cytokines; Cytokines - blood; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Fetal Blood - metabolism; Gestational Age; Gynecology. Andrology. Obstetrics; Humans; Infant, Newborn; Infant, Premature; Inflammation; Interleukin-6 - blood; Interleukin-8 - blood; Lung Diseases - blood; Lung Diseases - diagnosis; Male; Medical sciences; Neonate; Predictive Value of Tests; Receptors, Tumor Necrosis Factor, Type I - blood; Respiratory Distress Syndrome, Newborn - blood; Respiratory Distress Syndrome, Newborn - diagnosis
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1016/j.ajog.2004.04.014

In order to predict the late-development of chronic lung disease of prematurity (CLD), cytokines in the cord blood were assessed in this study. Eighteen premature infants with CLD were enrolled. Cord blood plasma levels of cytokines of these infants and 12 control infants without CLD were measured including interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, soluble TNF receptor-I, and soluble IL-6 receptor using a cytometric bead array and an enzyme-linked immunosorbent assay. The cord blood IL-6, IL-8, and sTNFR-I levels were significantly elevated in CLD infants compared with those in control ( P < .05). IL-1β, IL-2, IL-4, IL-10, and IFN-γ were undetectable in both groups. CLD infants with maternal chorioamnionitis had higher IL-6 than those without chorioamnionitis ( P < .01). In CLD infants, IL-6 was higher in the infants who required prolonged oxygen therapy ( P < .05). Elevated inflammatory cytokines in the cord blood are associated with the progression to CLD.