Molecular recognition remolds the self-assembly of hydrogelators and increases the elasticity of the hydrogel by 10(6)-fold

Addition of vancomycin (1, the receptor) to the supramolecular hydrogel of self-assembled pyrene-d-Ala-d-Ala (2, the ligand) increases the storage modulus of the hydrogel of 2 by about 106-fold. Rheology, microscopy, and spectroscopy investigations suggest that the two-dimensional polymers, formed b...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2004-11, Vol.126 (46), p.15028-15029
Main Authors: Zhang, Yan, Yang, Zhimou, Yuan, Fang, Gu, Hongwei, Gao, Ping, Xu, Bing
Format: Article
Language:English
Subjects:
Biomimetic Materials - chemistry
Dipeptides - chemistry
Elasticity
Hydrogels - chemistry
Ligands
Models, Molecular
Stereoisomerism
Vancomycin - chemistry
Viscosity
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Summary:Addition of vancomycin (1, the receptor) to the supramolecular hydrogel of self-assembled pyrene-d-Ala-d-Ala (2, the ligand) increases the storage modulus of the hydrogel of 2 by about 106-fold. Rheology, microscopy, and spectroscopy investigations suggest that the two-dimensional polymers, formed by the ligand-receptor interaction between 1 and 2, and the self-dimerization of 1, are mainly responsible for the observed dramatic increase in elasticity.
ISSN:0002-7863
DOI:10.1021/ja044401g