Prognostic Value of Q Wave for Cardiovascular Death in a 19-Year Prospective Study of the Japanese General Population

Aim: Little is known about the prognostic value of q wave abnormality for cardiovascular disease (CVD) on a resting electrocardiogram (ECG) of the Japanese general population with an extremely low incidence of myocardial infarction. Methods: We followed 8,339 participants without a past and present...

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Bibliographic Details
Published in:Journal of Atherosclerosis and Thrombosis 2009, Vol.16(1), pp.40-50
Main Authors: Higashiyama, Aya, Hozawa, Atsushi, Murakami, Yoshitaka, Okamura, Tomonori, Watanabe, Makoto, Nakamura, Yasuyuki, Hayakawa, Takehito, Kadowaki, Takashi, Kita, Yoshikuni, Okayama, Akira, Ueshima, Hirotsugu
Format: Article
Language:English
Subjects:
Asian Continental Ancestry Group
Cardiovascular diseases
Cohort study
Death
Electrocardiography
Female
Hazard ratio
Heart diseases
Humans
Japan
Male
Middle Aged
Proportional Hazards Models
Prospective Studies
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Summary:Aim: Little is known about the prognostic value of q wave abnormality for cardiovascular disease (CVD) on a resting electrocardiogram (ECG) of the Japanese general population with an extremely low incidence of myocardial infarction. Methods: We followed 8,339 participants without a past and present history of CVD for 19 years. The multivariate-adjusted hazard ratio (HR) of q wave abnormality for CVD mortality was estimated by the Cox proportional hazards model. Results: The multivariate-adjusted HR of composite findings of moderate or severe q wave abnormality was 1.75 (95% confidence interval (CI): 0.973.17) for mortality due to CVD and 2.97 (95%CI: 1.436.16) due to heart diseases. The multivariate-adjusted HR of mild abnormality for mortality from heart diseases was 1.95 (95%CI: 1.003.81). The relationship between moderate or severe abnormalities and mortality from CVD was unchanged when participants with ST-T changes and high amplitude R waves were excluded and when participants were divided by the presence of major CVD risk factors such as hypertension. Q wave abnormality was not associated with the risk of stroke. Conclusion: Moderate or severe q wave abnormalities are prominent and important predictors of mortality due to CVD and heart disease in the Japanese general population without CVD history.
ISSN:1340-3478
1880-3873
DOI:10.5551/jat.E606