Nasal chondromesenchymal hamartoma: report of a case and review of the literature

The sinonasal region is the site of several hamartomatous lesions, the majority of which are mesenchymal, with vascular hamartomas predominating. The occurrence of hamartomas in the nasal cavity of infants and children is especially rare. Nasal chondromesenchymal hamartoma (NCMH) is a rare lesion of...

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Bibliographic Details
Published in:Pediatric and developmental pathology 2004-09, Vol.7 (5), p.517-520
Main Authors: Norman, Elizabeth S, Bergman, Simon, Trupiano, Jacqueline K
Format: Article
Language:English
Subjects:
Cartilage - metabolism
Cartilage - pathology
Child
Hamartoma - metabolism
Hamartoma - pathology
Humans
Immunohistochemistry
Male
Mesoderm - metabolism
Mesoderm - pathology
Paranasal Sinus Diseases - metabolism
Paranasal Sinus Diseases - pathology
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Summary:The sinonasal region is the site of several hamartomatous lesions, the majority of which are mesenchymal, with vascular hamartomas predominating. The occurrence of hamartomas in the nasal cavity of infants and children is especially rare. Nasal chondromesenchymal hamartoma (NCMH) is a rare lesion of the intranasal sinuses generally diagnosed in the newborn period, with the eldest reported patient presenting at 16 years of age. This neoplasm is composed of mesenchymal-stromal and chondroid tissue in varying proportions. It is felt to be analogous to the mesenchymal hamartoma of the chest wall, a lesion of similar histology generally involving the ribs and chest wall of neonates. To the best of our knowledge, only 14 cases of NCMH have been reported to date. We report a case of NCMH in an 11-year-old boy.
ISSN:1093-5266
1615-5742
DOI:10.1007/s10024-004-1003-2