A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population

Summary To investigate whether a C to G transversion at position 77 in exon A of the CD45 gene is associated with the development of diabetes mellitus type 1 (T1D), we studied 165 patients and 220 control individuals. The frequency of the 77G allele in the control group was 1.1%, which was not signi...

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Bibliographic Details
Published in:European journal of immunogenetics 2004-12, Vol.31 (6), p.245-247
Main Authors: Thude, H., Rosenhahn, S., Hunger-Dathe, W., Müller, U.-A., Barz, D.
Format: Article
Language:English
Subjects:
Diabetes Mellitus, Type 1 - genetics
Diabetes Mellitus, Type 1 - immunology
Exons
Genetic Predisposition to Disease
Genotype
Germany
Humans
Leukocyte Common Antigens - genetics
Leukocyte Common Antigens - immunology
Point Mutation
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Sequence Analysis, DNA
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Summary:Summary To investigate whether a C to G transversion at position 77 in exon A of the CD45 gene is associated with the development of diabetes mellitus type 1 (T1D), we studied 165 patients and 220 control individuals. The frequency of the 77G allele in the control group was 1.1%, which was not significantly different from the 1.2% found in the patient group (P = 0.922). The C to G transversion does not seem to be associated with susceptibility for T1D.
ISSN:0960-7420
1365-2370
DOI:10.1111/j.1365-2370.2004.00479.x