A PET provocation study of generalized social phobia

In an investigation of the neural circuits that may mediate the subjective experience of social phobia (SP), six male patients with a primary DSM-IV diagnosis of generalized social phobia watched, in the presence of a group of “communication experts,” a videotape of themselves giving an impromptu ta...

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Bibliographic Details
Published in:Psychiatry research 2004-11, Vol.132 (1), p.13-18
Main Authors: Van Ameringen, Michael, Mancini, Catherine, Szechtman, Henry, Nahmias, Claude, Oakman, Jonathan M., Hall, Geoffrey B.C., Pipe, Beth, Farvolden, Peter
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult and adolescent clinical studies
Anxiety
Anxiety disorders
Anxiety disorders. Neuroses
Biological and medical sciences
Cerebrovascular Circulation - physiology
Diagnostic and Statistical Manual of Mental Disorders
Frontal Lobe - blood supply
Frontal Lobe - physiopathology
Humans
Male
Medical sciences
Middle Aged
Neurobiology
Neuroimaging
Phobia
Phobic Disorders - diagnosis
Phobic Disorders - physiopathology
Positron emission tomography
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Social anxiety disorder
Social phobia
Videotape Recording
Visual Cortex - blood supply
Visual Cortex - physiopathology
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Summary:In an investigation of the neural circuits that may mediate the subjective experience of social phobia (SP), six male patients with a primary DSM-IV diagnosis of generalized social phobia watched, in the presence of a group of “communication experts,” a videotape of themselves giving an impromptu talk (Exposure condition). In the control Baseline condition, they viewed a videotape of a socially competent stranger giving a talk. Regional cerebral blood flow was measured thrice under each condition. The study revealed significant deactivations from Baseline during Exposure in the right lingual gyrus (BA 18) and in the right medial frontal gyrus (BA 11); significant activations during Exposure were not observed. Deactivation of these regions may reflect a strategy of visual avoidance employed by the patients to dampen their phobic experience.
ISSN:0925-4927
0165-1781
1872-7506
DOI:10.1016/j.pscychresns.2004.07.005