Detection and partial characterisation of two antibacterial factors from the excretions/secretions of the medicinal maggot Lucilia sericata and their activity against methicillin-resistant Staphylococcus aureus (MRSA)

Maggot therapy is a simple and highly successful method for cleansing infected and necrotic wounds. The use of maggots has become increasingly important in the treatment of non-healing wounds, particularly those infected with the multidrug-resistant pathogen, methicillin-resistant Staphylococcus aur...

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Bibliographic Details
Published in:Microbes and infection 2004-11, Vol.6 (14), p.1297-1304
Main Authors: Bexfield, Alyson, Nigam, Yamni, Thomas, Stephen, Ratcliffe, Norman A.
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibacterial
Bacteriology
Biological and medical sciences
Blowfly
Diptera - chemistry
Drug Resistance, Bacterial
Fundamental and applied biological sciences. Psychology
Hydrogen-Ion Concentration
Larva - chemistry
Lucilia sericata
Maggot therapy
Methicillin Resistance
Microbial Sensitivity Tests
Microbiology
Miscellaneous
Molecular Weight
MRSA
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - growth & development
Wounds
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Summary:Maggot therapy is a simple and highly successful method for cleansing infected and necrotic wounds. The use of maggots has become increasingly important in the treatment of non-healing wounds, particularly those infected with the multidrug-resistant pathogen, methicillin-resistant Staphylococcus aureus (MRSA). The increasing challenge concerning the treatment of MRSA infections and the recent finding of vancomycin-resistant strains of MRSA have elicited the search for novel antibacterial compounds and, in particular, investigations into the potent antibacterial mechanism(s) behind maggot therapy. In this study, we report that excretions/secretions (ES) from the blowfly, Lucilia sericata, exhibit potent, thermally stable, protease resistant antibacterial activity against MRSA in vitro. We describe the initial characterisation of two antibacterial factors from native ES of L. sericata. A small,
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2004.08.011