Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population

Patients with chronic heart failure (CHF) express enhanced catabolic metabolism finally resulting in overall weight loss, whereas adipokines might play a crucial role in signaling among tissues. The aim of this study was to investigate the possible associations of defined variability in leptin (dbSN...

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Bibliographic Details
Published in:Heart and vessels 2009-03, Vol.24 (2), p.131-137
Main Authors: Bienertová-Vašků, Julie Anna, Špinarová, Lenka, Bienert, Petr, Vašků, Anna
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomedical Engineering and Bioengineering
Cardiac Surgery
Cardiology
Case-Control Studies
Chronic Disease
Cytokines
Czech Republic
Female
Gene Frequency
Genetic Predisposition to Disease
Heart failure
Heart Failure - ethnology
Heart Failure - genetics
Heart Failure - physiopathology
Hormones
Humans
Leptin - genetics
Male
Medicine
Medicine & Public Health
Middle Aged
Odds Ratio
Original Article
Phenotype
Polymorphism, Single Nucleotide
Population genetics
Pro-Opiomelanocortin - genetics
Receptors, Leptin - genetics
Risk Assessment
Risk Factors
Severity of Illness Index
Stroke Volume - genetics
Vascular Surgery
Ventricular Function, Left - genetics
Whites - genetics
Young Adult
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Summary:Patients with chronic heart failure (CHF) express enhanced catabolic metabolism finally resulting in overall weight loss, whereas adipokines might play a crucial role in signaling among tissues. The aim of this study was to investigate the possible associations of defined variability in leptin (dbSNP ID rs7799039), proopiomelanocortin (dbSNP ID rs3754860 and dbSNP ID rs1009388), and leptin receptor gene (dbSNP rs1137101) with CHF and evaluate their potential as the CHF susceptibility genes. The case-control study comprised a total of 372 patients of Caucasian origin with chronic heart failure (New York Heart Association [NYHA] functional classes II–IV, ejection fraction (EF)
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-008-1090-5