Synthetic receptors for chemical sensors—subnano- and micrometre patterning by imprinting techniques

Antibody-like selectivities are introduced into man-made polymeric systems by means of molecular imprinting. On the molecular scale, organic contaminants in water were analysed by 10 MHz QCM sensors coated both with affinity layers and with selective imprinted polymers. Affinity layers, polystyrene/...

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Bibliographic Details
Published in:Biosensors & bioelectronics 2004-12, Vol.20 (6), p.1040-1044
Main Authors: Dickert, Franz L., Lieberzeit, Peter, Miarecka, Sylwia Gazda, Mann, Karl Jürgen, Hayden, Oliver, Palfinger, Christian
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomimetic Materials - chemistry
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
Biosensors
Biotechnology
Blood cell detection
Cell Separation - instrumentation
Cell Separation - methods
Coated Materials, Biocompatible - chemistry
Erythrocytes - cytology
Fundamental and applied biological sciences. Psychology
Immunoassay - instrumentation
Immunoassay - methods
Mass-sensitive sensors
Methods. Procedures. Technologies
Molecular imprinting
Nanotechnology - instrumentation
Nanotechnology - methods
Organic Chemicals - analysis
Solvent detection
Solvents - analysis
Surface Properties
Various methods and equipments
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Summary:Antibody-like selectivities are introduced into man-made polymeric systems by means of molecular imprinting. On the molecular scale, organic contaminants in water were analysed by 10 MHz QCM sensors coated both with affinity layers and with selective imprinted polymers. Affinity layers, polystyrene/silicone, yield sensor effects for aromatic hydrocarbons according to, e.g., molecular weight and solubilities, a prediction by molecular modelling is proposed. Imprinted layers, however, recognise molecular shapes: the lean toluene is favoured by factor of six to the more bulky o-xylene; even the three xylenes can be distinguished from each other. On the micrometre scale, erythrocytes of different blood groups are differentiated, although their geometrical shape is identical. In this case, the recognition is accomplished by a predefined hydrogen bonding network between excess OH groups of the polyurethane layer and the sugar molecules on the cell surface defining the blood group.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2004.07.011