Nucleic-acid-templated synthesis as a model system for ancient translation

The translation of nucleic acids into synthetic structures with expanded functional potential has been the subject of considerable research, with applications including small-molecule and polymer evolution, reaction discovery and sensing. Here, we review properties of nucleic-acid-templated synthesi...

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Bibliographic Details
Published in:Current opinion in chemical biology 2004-12, Vol.8 (6), p.645-653
Main Authors: Calderone, Christopher T, Liu, David R
Format: Article
Language:English
Subjects:
DNA - chemistry
Evolution, Molecular
Models, Chemical
Nucleic Acids - chemical synthesis
Nucleic Acids - chemistry
Protein Biosynthesis
Templates, Genetic
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Summary:The translation of nucleic acids into synthetic structures with expanded functional potential has been the subject of considerable research, with applications including small-molecule and polymer evolution, reaction discovery and sensing. Here, we review properties of nucleic-acid-templated synthesis in the context of requirements for prebiotic translation. This analysis highlights the chemical possibilities of ancient translation systems, as well as challenges that these systems may have faced.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2004.09.003