Nucleic-acid-templated synthesis as a model system for ancient translation

The translation of nucleic acids into synthetic structures with expanded functional potential has been the subject of considerable research, with applications including small-molecule and polymer evolution, reaction discovery and sensing. Here, we review properties of nucleic-acid-templated synthesi...

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Published in:Current opinion in chemical biology 2004-12, Vol.8 (6), p.645-653
Main Authors: Calderone, Christopher T, Liu, David R
Format: Article
Language:English
Subjects:
DNA - chemistry
Evolution, Molecular
Models, Chemical
Nucleic Acids - chemical synthesis
Nucleic Acids - chemistry
Protein Biosynthesis
Templates, Genetic
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description The translation of nucleic acids into synthetic structures with expanded functional potential has been the subject of considerable research, with applications including small-molecule and polymer evolution, reaction discovery and sensing. Here, we review properties of nucleic-acid-templated synthesis in the context of requirements for prebiotic translation. This analysis highlights the chemical possibilities of ancient translation systems, as well as challenges that these systems may have faced.
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subjects DNA - chemistry
Evolution, Molecular
Models, Chemical
Nucleic Acids - chemical synthesis
Nucleic Acids - chemistry
Protein Biosynthesis
Templates, Genetic
title Nucleic-acid-templated synthesis as a model system for ancient translation
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