Impact of impaired myocardial deformations on exercise tolerance and prognosis in patients with asymptomatic aortic stenosis

Aims As assessed by tissue Doppler velocities, longitudinal contraction is commonly altered at an earlier stage than radial contraction in patients with severe aortic stenosis (AS). However, its relationship to exercise tolerance or to prognosis has not been clearly established. By using two-dimensi...

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Bibliographic Details
Published in:European journal of echocardiography 2009-05, Vol.10 (3), p.414-419
Main Authors: Lafitte, Stéphane, Perlant, Matthieu, Reant, Patricia, Serri, Karim, Douard, Herve, DeMaria, Anthony, Roudaut, Raymond
Format: Article
Language:English
Subjects:
Aged
Aortic Valve Stenosis - diagnostic imaging
Aortic Valve Stenosis - physiopathology
Double-Blind Method
Echocardiography, Doppler - methods
Echocardiography, Doppler - statistics & numerical data
Electrocardiography
Exercise Test - methods
Exercise Tolerance - physiology
Female
Follow-Up Studies
Humans
Male
Myocardial Contraction - physiology
Observer Variation
Prognosis
Prospective Studies
Risk Factors
Sensitivity and Specificity
Treatment Outcome
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Summary:Aims As assessed by tissue Doppler velocities, longitudinal contraction is commonly altered at an earlier stage than radial contraction in patients with severe aortic stenosis (AS). However, its relationship to exercise tolerance or to prognosis has not been clearly established. By using two-dimensional (2D) echocardiographic strain, we sought to evaluate values of deformation components in the setting of severe AS and to correlate these values with exercise tolerance and with patients' outcome. Methods and results Sixty-five asymptomatic patients with severe AS (aortic valve area
ISSN:1525-2167
1532-2114
DOI:10.1093/ejechocard/jen299