Cytomegalovirus-associated Discrete Gastrointestinal Masses in Macaques Infected with the Simian Immunodeficiency Virus

Cytomegalovirus (CMV)-associated gastrointestinal masses have been reported in human acquired immune deficiency syndrome patients. This is the first report on CMV-associated gastrointestinal masses in simian immunodeficiency virus (SIV)-infected macaques. Two SIV-infected macaques presented at necro...

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Bibliographic Details
Published in:Veterinary pathology 2004-11, Vol.41 (6), p.691-695
Main Authors: Hutto, E. Hendricks, Anderson, D. C., Mansfield, K. G.
Format: Article
Language:English
Subjects:
Animals
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - pathology
Cytomegalovirus Infections - veterinary
Female
Gastritis, Hypertrophic - veterinary
Gastritis, Hypertrophic - virology
Gastrointestinal Diseases - pathology
Gastrointestinal Diseases - veterinary
Gastrointestinal Diseases - virology
Macaca - virology
Male
Monkey Diseases - pathology
Monkey Diseases - virology
Simian Acquired Immunodeficiency Syndrome - complications
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Summary:Cytomegalovirus (CMV)-associated gastrointestinal masses have been reported in human acquired immune deficiency syndrome patients. This is the first report on CMV-associated gastrointestinal masses in simian immunodeficiency virus (SIV)-infected macaques. Two SIV-infected macaques presented at necropsy with multiple nodular or umbilicated masses within the gastrointestinal tract. In one animal, the masses were located throughout the gastrointestinal tract, whereas in the other, the masses were restricted to the proximal small intestine. Grossly, the masses were indistinguishable from those caused by neoplastic conditions such as lymphoma and, histologically, were composed of hyperplastic glandular tissue, dense neutrophilic infiltrates within the lamina propria, and multifocal proprial hemorrhage. Frequent cytomegalic cells with basophilic intranuclear inclusions were found in affected regions. Immunohistochemistry for CMV demonstrated frequent immunopositive cells within affected areas. Furthermore, immunohistochemistry for the proliferation marker Ki-67 demonstrated increased proliferation in hyperplastic glands and crypts. CMV should be considered a cause of discrete mass lesions in the gastrointestinal tract of SIV-infected macaques.
ISSN:0300-9858
1544-2217
DOI:10.1354/vp.41-6-691