Ribosome synthesis meets the cell cycle

A large number of ribosome synthesis factors have been identified using proteomic analyses in yeast. The patterns of RNA and protein co-precipitation suggest that ribosome synthesis does not proceed via a linear progression of successive steps. Recent analyses have identified several interactions be...

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Bibliographic Details
Published in:Current opinion in microbiology 2004-12, Vol.7 (6), p.631-637
Main Authors: Dez, Christophe, Tollervey, David
Format: Article
Language:English
Subjects:
Cell Cycle - physiology
Gene Expression Regulation, Fungal
Ribosomal Proteins - genetics
Ribosomal Proteins - metabolism
Ribosomes - genetics
Ribosomes - metabolism
Saccharomyces cerevisiae - cytology
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
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Summary:A large number of ribosome synthesis factors have been identified using proteomic analyses in yeast. The patterns of RNA and protein co-precipitation suggest that ribosome synthesis does not proceed via a linear progression of successive steps. Recent analyses have identified several interactions between factors clearly implicated in ribosome synthesis and specific steps in the cell division cycle. The intersections between these pathways were not anticipated, but potential explanations for their existence can be advanced.
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2004.10.007